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Cat-scratch Disease: Therapy With Trimethoprim-Sulfamethoxazole FREE

PLATON J. COLLIPP, MD
Am J Dis Child. 1992;146(4):397-399. doi:10.1001/archpedi.1992.02160160017006.
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Sir.—Cat-scratch disease generally consists of regional lymphadenitis due to a gram-negative bacillus acquired from cats. There is often a small red papule or an infected scratch near the involved lymph node. Complications or other manifestations of the disease have included conjunctivitis, encephalopathy, peripheral neuropathy, osteolytic lesions, and polyneuritis. Treatment with oral trimethoprim-sulfamethoxazole was reported recently.1 This report extends those observations.

Patients and Methods.—A retrospective review of 50 000 patient visits to a pediatric office in southeast Georgia from 1984 to 1990 disclosed the cases diagnosed as cat-scratch disease, lymphadenitis, regional lymphadenopathy, and adenitis. Patients with generalized adenopathy, bilateral adenopathy, and lymphadenopathy with splenomegaly were excluded. All patients were questioned carefully about exposure to cats at their home, their relatives' or friends' homes, or elsewhere.

Cat-scratch skin tests were applied at least 7 days after the onset of illness and the results read 2 to 3 days later

REFERENCES

Collipp PJ.  Cat-scratch disease therapy . AJDC . 1989;;143:1261.
Holley HP.  Successful treatment of cat-scratch disease with ciprofloxacin . JAMA . 1991;;265:1563-1565.
Bogue CW, Wise JD, Gray GF, Edward KM.  Antibiotic therapy for cat-scratch disease . JAMA . 1989;;262:813-816.
Rudikoff D, Phelps RG, Gordon RE.  Acquired immunodeficiency syndrome related bacillary vascular proliferation (epithelioid angiomatosis): rapid response to erythromycin therapy . Arch Dermatol . 1989;;125:706.
Carithers HA.  Cat-scratch disease: an overview based on a study of 1200 patients . AJDC . 1985;;139:1124-1133.
Carithers HA, Margileth AM.  Cat-scratch disease, acute encephalopathy, and other neurologic manifestations . AJDC . 1991;; 145:98-101.
Margileth AM, Hadfield TL.  A new look at old cat scratch . Contemp Pediatr . 1990;;7: 25-48.

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References

Collipp PJ.  Cat-scratch disease therapy . AJDC . 1989;;143:1261.
Holley HP.  Successful treatment of cat-scratch disease with ciprofloxacin . JAMA . 1991;;265:1563-1565.
Bogue CW, Wise JD, Gray GF, Edward KM.  Antibiotic therapy for cat-scratch disease . JAMA . 1989;;262:813-816.
Rudikoff D, Phelps RG, Gordon RE.  Acquired immunodeficiency syndrome related bacillary vascular proliferation (epithelioid angiomatosis): rapid response to erythromycin therapy . Arch Dermatol . 1989;;125:706.
Carithers HA.  Cat-scratch disease: an overview based on a study of 1200 patients . AJDC . 1985;;139:1124-1133.
Carithers HA, Margileth AM.  Cat-scratch disease, acute encephalopathy, and other neurologic manifestations . AJDC . 1991;; 145:98-101.
Margileth AM, Hadfield TL.  A new look at old cat scratch . Contemp Pediatr . 1990;;7: 25-48.

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