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March 1992, Vol 146, No. 3 >
Article | March 1992

Beneficial Effects of Dietary Intervention on Serum Lipid and Apolipoprotein Levels in Obese Children FREE

Hiroomi Endo, MD; Yasuo Takagi, MD; Tomio Nozue, MD; Keiko Kuwahata, MD; Fujio Uemasu, MD; Ario Kobayashi, MD
[+] Author Affiliations

Accepted for publication April 8, 1991.

Read before the 14th International Congress of Nutrition, Seoul, South Korea, August 24, 1989.

Reprint requests to Department of Pediatrics, Showa University Toyosu Hospital, Toyosu 4-1-18, Koto-ku, 135 Tokyo, Japan (Dr Endo).


Am J Dis Child. 1992;146(3):303-305. doi:10.1001/archpedi.1992.02160150043017.
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• Effects of weight reduction on serum levels of lipids and apolipoproteins were measured in 13 obese children (seven girls, six boys). Mean weight loss of 8.4% of the initial body weight was achieved after 4 weeks of energy intake restriction and exercise. Serum total cholesterol (5.46±1.01 mmol/L) and triglyceride (2.08±0.52 mmol/L) levels were significantly high compared with control values before treatment and were significantly reduced to 4.32±0.75 and 1.31 ±0.42 mmol/L, respectively, after treatment. Serum high-density lipoprotein cholesterol level (1.03±0.23 mmol/L) was significantly low and unchanged after treatment (0.94±0.25 mmol/L). Serum apolipoprotein A-I level (0.039±0.009 mmol/L or 111 ± 0.26 g/L) was normal before treatment and significantly reduced, to 0.032±0.007 mmol/L or 0.92±0.19 g/L, after weight reduction. Serum apolipoprotein B level (0.00019±0.00007 mmol/L or 1.07±0.21 g/L) was significantly high before treatment and decreased to the normal range after treatment (0.00014±0.0009 mmol/L or 0.76±0.24 g/L). The ratio of apolipoprotein B to apolipoprotein A-I (1.09±0.29) was significantly high on admission and decreased significantly to 0.64±0.12 after treatment. Serum apolipoprotein E level (0.0014±0.0006 mmol/L or 0.05 ±0.02 g/L) was normal and decreased to 0.0008±0.0002 mmol/L or 0.03±0.01 g/L after treatment. In conclusion, weight reduction achieved by energy intake restriction and exercise had beneficial effects on serum lipid and apolipoprotein concentrations for the prevention of future atherosclerosis.

(AJDC. 1992;146:303-305)

REFERENCES

1 +
Freedman DS, Burke GL, Harsha DW, et al.  Relationship of changes in obesity to serum lipid and lipoprotein changes in childhood and adolescence . JAMA . 1985;;254:515-520.
2 +
Voors AW, Harsha DW, Webber LS, Radhahrishnamurthy B, Srinivasan SR, Berenson GS.  Clustering of anthropometric parameters, glucose tolerance, and serum lipids in children with high and low β- and pre-β-lipoproteins . Arteriosclerosis . 1982;;2:346-355.
3 +
Tokunaga K, Ishikawa K, Sudo H, Mastuzawa Y, Yamamoto A, Tarui S.  Serum lipoprotein profile in Japanese obese children . Int J Obes . 1981;;6:399-404.
4 +
Hubert HB, Feinlieb M, McNamara PM, Castelli WP.  Obesity as an independent risk factor for cardiovascular disease: a 26-year follow-up of participants in the Framingham heart study . Circulation . 1983;;67:968-977.
5 +
Zimmerman J, Kaufman NA, Fainaru M, et al.  Effect of weight loss in moderate obesity on plasma lipoprotein and apolipoprotein levels and high density lipoprotein composition . Arteriosclerosis . 1984;;4:115-123.
6 +
Wood PD, Stefanick ML, Dreon DM, et al.  Changes in plasma lipids and lipoproteins in overweight men during weight loss through dieting as compared with exercise . N Engl J Med . 1988;;319:1173-1179.
7 +
Sopko G, Leon AS, Jacobs DR Jr, et al.  The effects of exercise and weight loss on plasma lipids in young obese men . Metabolism . 1985;;34:227-236.
8 +
Valanta LJ, Elias AN.  Modified fasting in treatment of obesity: effects on serum lipids, electrolytes, liver enzymes, and blood pressure . Postgrad Med . 1989;;79:263-267.
9 +
Contaldo F, Storazzullo P, Postiglione A, et al.  Plasma high density lipoprotein in severe obesity after stable weight loss . Atherosclerosis . 1980;;37:163-167.
10 +
Brownell KD, Stunkard AJ.  Differential changes in plasma high density lipoprotein-cholesterol levels in obese men and women during weight reduction . Arch Intern Med . 1981;;141:1142-1146.
11 +
Thompson PD, Jeffery RW, Wing RR, Wood PD.  Unexpected decrease in plasma high density lipoprotein cholesterol with weight loss . Am J Clin Nutr . 1979;;32:2016-2021.
12 +
Friedman Cl, Falko JM, Patel ST, Kin MH, Newman HAI, Barrows H.  Serum lipoprotein responses during active and stable weight reduction in reproductive obese females . J Clin Endocrinol Metab . 1982;;55:258-262.
13 +
Wolf RN, Grundy SM.  Influence of weight reduction on plasma lipoproteins in obese patients . Arteriosclerosis . 1983;;3:160-169.
14 +
Schwartz RS.  The independent effects of dietary weight loss and aerobic training in high density lipoproteins and apolipoproteins A-l concentrations in obese men . Metabolism . 1987;;6:165-171.
15 +
Wood PD, Haskell WL, Blair SN, et al.  Increased exercise level and plasma lipoprotein concentrations: a one-year, randomized, controlled study of sedentary, middle-aged men . N Engl J Med . 1983;;32:31-39.
16 +
Sörbris R, Petersson BG, Nilsson-Ehle P.  Effects of weight reduction on plasma lipoproteins and adipose tissue metabolism in obese subjects . Eur J Clin Invest . 1981;;11:491-498.
17 +
Brozek JF, Grand F, Anderson JT, Keys A.  Densitometric analysis of body compositions: revision of some quantitative assumptions . Ann N Y Acad Sci . 1963;;10:113-140.
18 +
Endo H, Takayanagi T, Kuwahata K, Nozue T, Takagi Y, Kobayashi A.  Serum concentration of apolipoproteins in healthy Japanese children . Jpn J Pediatr Gastroenterol Nutr . 1989;;3:319-326.
19 +
Albrink MJ, Meigs JW, Granoff MA.  Weight gain and serum triglycerides in normal men . N Engl J Med . 1962;;266:484-489.
20 +
Avogaro P, Bon GB, Bellussi F, Cazzolato G.  Relationships of body weight and fatness to lipoprotein components: variations following hypocaloric diet . Prog Biochem Pharmacol . 1983;;19:141-150.
21 +
Wilson PW, McGee DL, Kannel WB.  Factors associated with lipoprotein cholesterol levels: the Framingham study . Arteriosclerosis . 1983;;3:273-281.
22 +
Dennison BA, Kikuchi DA, Srinivasan SR, Webber LS, Berenson GS.  Measurement of apolipoprotein B as a screening test for identifying children with elevated levels of low-density lipoprotein cholesterol . J Pediatr . 1990;;117:358-363.
23 +
Riesen WF, Mordasini R, Salzmann C, Theler A, Gurtner HP.  Apoproteins and lipids as discriminators of severity of coronary heart disease . Atherosclerosis . 1980;;37:157-162.
24 +
Maciejko JJ, Holmes DR, Kottke BA, Zinsmeister AR, Dish DM, Mao SJT.  Apolipoprotein A-I as a marker of angiographically assessed coronary artery disease . N Engl J Med . 1983;;309:385-389.
25 +
Durrington PN, Hunt L, Ishola M, Kane J, Stephens WR.  Serum apolipoproteins Al and B and lipoproteins in middle aged men with and without previous myocardial infarction . Br Heart J . 1986;;56:206-212.
26 +
Baker GD, Rosseneu M, Deslypere JP.  Discriminative value of lipids and apoproteins in coronary heart disease . Atherosclerosis . 1982;;42:197-203.
27 +
Noma A, Yokosuka T, Kitammura K.  Plasma lipids and apolipoproteins as discriminators for presence and severity of angiographically defined coronary artery disease . Atherosclerosis . 1983;;49:1-7.
28 +
Van Stiphout WAHJ, Hofman A, Kruijssen HACM, Vermeeren R, Groot PHE.  Is the ratio of apoB/apoA-I an early predictor of coronary atherosclerosis . Atherosclerosis . 1986;; 62:179-182.
29 +
Perosa N, Aingorn H, Metelskaya V, Dorofeeva T, Belokonj N.  Plasma lipid and apolipoprotein levels in children hereditarily predisposed to coronary heart disease . Acta Scand Pediatr . 1988;;77:559-562.

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References

1 +
Freedman DS, Burke GL, Harsha DW, et al.  Relationship of changes in obesity to serum lipid and lipoprotein changes in childhood and adolescence . JAMA . 1985;;254:515-520.
2 +
Voors AW, Harsha DW, Webber LS, Radhahrishnamurthy B, Srinivasan SR, Berenson GS.  Clustering of anthropometric parameters, glucose tolerance, and serum lipids in children with high and low β- and pre-β-lipoproteins . Arteriosclerosis . 1982;;2:346-355.
3 +
Tokunaga K, Ishikawa K, Sudo H, Mastuzawa Y, Yamamoto A, Tarui S.  Serum lipoprotein profile in Japanese obese children . Int J Obes . 1981;;6:399-404.
4 +
Hubert HB, Feinlieb M, McNamara PM, Castelli WP.  Obesity as an independent risk factor for cardiovascular disease: a 26-year follow-up of participants in the Framingham heart study . Circulation . 1983;;67:968-977.
5 +
Zimmerman J, Kaufman NA, Fainaru M, et al.  Effect of weight loss in moderate obesity on plasma lipoprotein and apolipoprotein levels and high density lipoprotein composition . Arteriosclerosis . 1984;;4:115-123.
6 +
Wood PD, Stefanick ML, Dreon DM, et al.  Changes in plasma lipids and lipoproteins in overweight men during weight loss through dieting as compared with exercise . N Engl J Med . 1988;;319:1173-1179.
7 +
Sopko G, Leon AS, Jacobs DR Jr, et al.  The effects of exercise and weight loss on plasma lipids in young obese men . Metabolism . 1985;;34:227-236.
8 +
Valanta LJ, Elias AN.  Modified fasting in treatment of obesity: effects on serum lipids, electrolytes, liver enzymes, and blood pressure . Postgrad Med . 1989;;79:263-267.
9 +
Contaldo F, Storazzullo P, Postiglione A, et al.  Plasma high density lipoprotein in severe obesity after stable weight loss . Atherosclerosis . 1980;;37:163-167.
10 +
Brownell KD, Stunkard AJ.  Differential changes in plasma high density lipoprotein-cholesterol levels in obese men and women during weight reduction . Arch Intern Med . 1981;;141:1142-1146.
11 +
Thompson PD, Jeffery RW, Wing RR, Wood PD.  Unexpected decrease in plasma high density lipoprotein cholesterol with weight loss . Am J Clin Nutr . 1979;;32:2016-2021.
12 +
Friedman Cl, Falko JM, Patel ST, Kin MH, Newman HAI, Barrows H.  Serum lipoprotein responses during active and stable weight reduction in reproductive obese females . J Clin Endocrinol Metab . 1982;;55:258-262.
13 +
Wolf RN, Grundy SM.  Influence of weight reduction on plasma lipoproteins in obese patients . Arteriosclerosis . 1983;;3:160-169.
14 +
Schwartz RS.  The independent effects of dietary weight loss and aerobic training in high density lipoproteins and apolipoproteins A-l concentrations in obese men . Metabolism . 1987;;6:165-171.
15 +
Wood PD, Haskell WL, Blair SN, et al.  Increased exercise level and plasma lipoprotein concentrations: a one-year, randomized, controlled study of sedentary, middle-aged men . N Engl J Med . 1983;;32:31-39.
16 +
Sörbris R, Petersson BG, Nilsson-Ehle P.  Effects of weight reduction on plasma lipoproteins and adipose tissue metabolism in obese subjects . Eur J Clin Invest . 1981;;11:491-498.
17 +
Brozek JF, Grand F, Anderson JT, Keys A.  Densitometric analysis of body compositions: revision of some quantitative assumptions . Ann N Y Acad Sci . 1963;;10:113-140.
18 +
Endo H, Takayanagi T, Kuwahata K, Nozue T, Takagi Y, Kobayashi A.  Serum concentration of apolipoproteins in healthy Japanese children . Jpn J Pediatr Gastroenterol Nutr . 1989;;3:319-326.
19 +
Albrink MJ, Meigs JW, Granoff MA.  Weight gain and serum triglycerides in normal men . N Engl J Med . 1962;;266:484-489.
20 +
Avogaro P, Bon GB, Bellussi F, Cazzolato G.  Relationships of body weight and fatness to lipoprotein components: variations following hypocaloric diet . Prog Biochem Pharmacol . 1983;;19:141-150.
21 +
Wilson PW, McGee DL, Kannel WB.  Factors associated with lipoprotein cholesterol levels: the Framingham study . Arteriosclerosis . 1983;;3:273-281.
22 +
Dennison BA, Kikuchi DA, Srinivasan SR, Webber LS, Berenson GS.  Measurement of apolipoprotein B as a screening test for identifying children with elevated levels of low-density lipoprotein cholesterol . J Pediatr . 1990;;117:358-363.
23 +
Riesen WF, Mordasini R, Salzmann C, Theler A, Gurtner HP.  Apoproteins and lipids as discriminators of severity of coronary heart disease . Atherosclerosis . 1980;;37:157-162.
24 +
Maciejko JJ, Holmes DR, Kottke BA, Zinsmeister AR, Dish DM, Mao SJT.  Apolipoprotein A-I as a marker of angiographically assessed coronary artery disease . N Engl J Med . 1983;;309:385-389.
25 +
Durrington PN, Hunt L, Ishola M, Kane J, Stephens WR.  Serum apolipoproteins Al and B and lipoproteins in middle aged men with and without previous myocardial infarction . Br Heart J . 1986;;56:206-212.
26 +
Baker GD, Rosseneu M, Deslypere JP.  Discriminative value of lipids and apoproteins in coronary heart disease . Atherosclerosis . 1982;;42:197-203.
27 +
Noma A, Yokosuka T, Kitammura K.  Plasma lipids and apolipoproteins as discriminators for presence and severity of angiographically defined coronary artery disease . Atherosclerosis . 1983;;49:1-7.
28 +
Van Stiphout WAHJ, Hofman A, Kruijssen HACM, Vermeeren R, Groot PHE.  Is the ratio of apoB/apoA-I an early predictor of coronary atherosclerosis . Atherosclerosis . 1986;; 62:179-182.
29 +
Perosa N, Aingorn H, Metelskaya V, Dorofeeva T, Belokonj N.  Plasma lipid and apolipoprotein levels in children hereditarily predisposed to coronary heart disease . Acta Scand Pediatr . 1988;;77:559-562.

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