Article |

Cocaine-Associated Abnormalities May Not Be Causally Related

Am J Dis Child. 1992;146(3):278. doi:10.1001/archpedi.1992.02160150016007.
Text Size: A A A
Published online

Sir.—Dominguez et al1 implicate in utero exposure to cocaine and other vasoactive drugs as the cause of brain and ocular abnormalities. However, their conclusions are drawn from a case study of 10 infants with no comparison group. Since prenatal drug exposure is associated with many potential confounding variables,2 the attribution of their findings to such exposure is unwarranted without further study.

The professional and lay media are saturated with reports of multiple adverse effects ofcocaine and other drugs on the fetus and newborn, mostly based on preliminary data or inadequately performed studies. While there is good reason to suspect adverse effects of such drugs, there is also potential danger in inappropriately expecting damage in these children. The risk of cocaine and other vasoactive drugs to the developingfetus and newborn should be fairly estimated by well-designed studies. Uncontrolled case studies may be valuable to generate hypotheses, not to test them.


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview





Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.