Neurodevelopmental Outcome of Offspring of the Diabetic Mother: Need for Further Research FREE

ESTHER GOLDSTEIN, PHD; BASIL PORTER, MBBCH; AHARON GALIL, MD

Am J Dis Child. 1991;145(6):602-603. doi:10.1001/archpedi.1991.02160060018010.

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ABSTRACT

ABSTRACT | REFERENCES

Sir.—The improved care of diabetic women prior to conception and during pregnancy has significantly decreased the incidence of mortality, morbidity, and congenital anomalies in the infants of these diabetic mothers.^1-3 However, postnatal complications still occur more frequently among these infants than among infants of nondiabetic mothers.^4-8 The significance of these complications for the developing child of the diabetic mother must be established to determine whether the complications at birth predispose these children to later neurodevelopmental dysfunction.

An analysis of the results of follow-up studies of children whose mothers had diabetes during pregnancy should address this issue. Results of five major follow-up studies have been published between 1977 and 1988.^9-13 However, the results have often been contradictory and limited by methodologic flaws. For example, only two of the studies employed control groups.^12,13 In all the studies, sample sizes were relatively small (73 to 174 children)

REFERENCES

ABSTRACT | REFERENCES

Fleischman AR, Finberg L. The infant of the diabetic mother and diabetes in infancy . In: Ellenberg M, Rifkin H, eds. Diabetes Mellitus . 3rd ed. New York, NY: Medical Examination Publishing Co; 1983;:715-725.

Schwartz R. The infant of the diabetic mother . In: Davidson JK, ed. Clinical Diabetes Mellitus . New York, NY: Thieme-Stratton Inc; 1986;:496-504.

Damm P, Molsted-Pedersen L. Significant decrease in congenital malformation in newborn infants of an unselected population of diabetic women . Am J Obstet Gynecol . 1989;;161:1163-1167.

Fraser D, Weitzman S. Diabetes in pregnancy and the newborns of diabetic mothers . In: Epidemiology in Diabetes . Beer Sheva, Israel: Israeli National Council for Research and Development; 1989;.

Drexel H, Bichler A, Sailer S, et al. Prevention of perinatal morbidity by tight metabolic control in gestational diabetes mellitus . Diabetes Care . 1988;; 11:761-768.

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Stehbens JA, Baker GL, Kitchell M. Outcome at ages 1,3, and 5 years of children born to diabetic women . Am J Obstet Gynecol . 1977;;127:408-413.

Cummins M, Norrish M. Follow-up of children of diabetic mothers . Arch Dis Child. 1980;;55:259-264.

Persson B, Gentz J. Follow-up of children of insulin dependent and gestational diabetic mothers . Acta Paediatr Scand. 1984;;73:349-358.

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Petersen MB, Pedersen SA, Greisen G, Pedersen JF, Molsted-Pedersen L. Early growth delay in diabetic pregnancy: relation to psychomotor development at age 4 . Br Med J. 1988;;296:598-600.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal