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November 1990, Vol 144, No. 11 >
Article | November 1990

Immune Complexes in Pediatric Human Immunodeficiency Virus Infection FREE

Maadhava Ellaurie, MD; Theresa Calvelli, PhD; Arye Rubinstein, MD
[+] Author Affiliations

Accepted for publication April 10, 1990.

Reprint requests to Department of Pediatrics, Albert Einstein College of Medicine, 1300 Morris Park Ave, Room 401, Forchheimer Bldg, Bronx, NY 10461 (Dr Rubinstein).


Am J Dis Child. 1990;144(11):1207-1209. doi:10.1001/archpedi.1990.02150350039020.
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References
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• Circulating immune complexes (CIC) were analyzed in a cohort of 30 children infected with the human immunodeficiency virus. Elevated CIC were detected by the C1 q assay in 70% (21/30) of all patients and by the Raji cell assay in 93% (28/30) of all patients. While only less than one third of patients with elevated CIC had free serum antibodies to Epstein-Barr virus, 80% (16/20) of them had detectable antibodies to Epstein-Barr virus associated with CIC. Enriched CIC in human immunodeficiency virus–infected children contained low levels of complement. These findings document that, as an expression of the humoral immunodeficiency, CIC in human immunodeficiency virus–infected children are deficient in complement and can thus be underestimated if complement-precipitating methods are used for their detection.

(AJDC. 1990;144:1207-1209)

REFERENCES

1 +
Quinnan GV, Siegel JP, Epstein JS, Manischewitz JF, Barnes S, Wells MA.  Mechanisms of T-cell functional deficiency in the acquired immunodeficiency syndrome . Ann Intern Med . 1985;;103: 710-714.
2 +
Klatzman D, Barre-Sinoussi F, Nugeyre MT, et al.  Selective tropism of lymphoadenopathy associated virus for helper-induced T lymphocytes . Science . 1984;;225:59-63.
3 +
Euler HH, Kern P, Loffler H, Dietrich M.  Precipitable immune complexes in healthy homosexual men, acquired immune deficiency syndrome and the related lymphadenopathy syndrome . Clin Exp Immunol . 1985;;59:267-275.
4 +
McDougal SJ, Hubbard M, Nicholson JK, Jones BM.  Immune complexes in the acquired immunodeficiency syndrome (AIDS): relationship to disease manifestation, risk group, and immunologic defect . J Clin Immunol . 1985;;5:130-138.
5 +
Calvelli TA, Rubinstein A.  Intravenous gamma globulin in infant acquired immunodeficiency syndrome . Pediatr Infect Dis . 1986;;5:207-210.
6 +
Ellaurie M, Calvelli TA, Rubinstein A.  Effect of IVIG on circulating immune complexes (CIC) in pediatric AIDS/ARC . Pediatr Res . 1987;;21:311A. Abstract.
7 +
Morrow WJW, Wharton M, Stricker R, Levy JA.  Circulating immune complexes in patients with acquired immune deficiency syndrome contain the AIDS-associated retrovirus . Clin Immunol Immunopathol . 1986;;40:515-524.
8 +
Carini C, Messaroma I, Scano G, D'Amelio R, Matricardi P, Aiuti F.  Characterization of specific immune complexes in HIV related disorders . Scand J Immunol . 1987;;26:21-28.
9 +
Centers for Disease Control.  Classification system for HIV infection in children under 13 years of age . MMWR . 1987;;36:225-236.
10 +
Theofilopoulos AN, Dixon FJ, Bokisch VA.  Binding of soluble immune complexes to human lymphoblastoid cells: characterization of receptors for IgG Fc and complement and description of the binding mechanism . J Exp Med . 1974;;140:877-894.
11 +
Zubler RH, Lange G, Lambert PH, Miescher PA.  Detection of immune complexes in unheated sera by a modified 125I Clq binding test . J Immunol . 1976;;116:232-235.
12 +
Hudson L, Hay FC. Practical Immunology . Boston, Mass: Blackwell Scientific Publications Inc; 1976;: chap 8 .
13 +
Bernstein LJ, Ochs HD, Wedgewood RJ, Rubinstein A.  Defective humoral immunity in pediatric acquired immune deficiency syndrome . J Pediatr . 1985;;107:352-357.
14 +
Espinoza LR, Osterland CK. Assays for Circulating Immune Complexes . New York, NY: Futura Publishing Co; 1983;:24.
15 +
Bender BS, Bohnsack JF, Sourlis SH, Frank MM, Quinn TC.  Demonstration of defective C3-receptor mediated clearance by the reticulo-endothelial system in patients with acquired immunodeficiency syndrome . JCI . 1987;;79:715-720.
16 +
Gupta S, Licorish K.  Circulating immune complexes in AIDS . N Engl J Med . 1984;;310:1530-1531.
17 +
Rubinstein A, Morecki R, Silverman B, et al.  Pulmonary disease in children with acquired immunodeficiency syndrome and AIDS-related complex . J Pediatr . 1986;;108:498-503.

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References

1 +
Quinnan GV, Siegel JP, Epstein JS, Manischewitz JF, Barnes S, Wells MA.  Mechanisms of T-cell functional deficiency in the acquired immunodeficiency syndrome . Ann Intern Med . 1985;;103: 710-714.
2 +
Klatzman D, Barre-Sinoussi F, Nugeyre MT, et al.  Selective tropism of lymphoadenopathy associated virus for helper-induced T lymphocytes . Science . 1984;;225:59-63.
3 +
Euler HH, Kern P, Loffler H, Dietrich M.  Precipitable immune complexes in healthy homosexual men, acquired immune deficiency syndrome and the related lymphadenopathy syndrome . Clin Exp Immunol . 1985;;59:267-275.
4 +
McDougal SJ, Hubbard M, Nicholson JK, Jones BM.  Immune complexes in the acquired immunodeficiency syndrome (AIDS): relationship to disease manifestation, risk group, and immunologic defect . J Clin Immunol . 1985;;5:130-138.
5 +
Calvelli TA, Rubinstein A.  Intravenous gamma globulin in infant acquired immunodeficiency syndrome . Pediatr Infect Dis . 1986;;5:207-210.
6 +
Ellaurie M, Calvelli TA, Rubinstein A.  Effect of IVIG on circulating immune complexes (CIC) in pediatric AIDS/ARC . Pediatr Res . 1987;;21:311A. Abstract.
7 +
Morrow WJW, Wharton M, Stricker R, Levy JA.  Circulating immune complexes in patients with acquired immune deficiency syndrome contain the AIDS-associated retrovirus . Clin Immunol Immunopathol . 1986;;40:515-524.
8 +
Carini C, Messaroma I, Scano G, D'Amelio R, Matricardi P, Aiuti F.  Characterization of specific immune complexes in HIV related disorders . Scand J Immunol . 1987;;26:21-28.
9 +
Centers for Disease Control.  Classification system for HIV infection in children under 13 years of age . MMWR . 1987;;36:225-236.
10 +
Theofilopoulos AN, Dixon FJ, Bokisch VA.  Binding of soluble immune complexes to human lymphoblastoid cells: characterization of receptors for IgG Fc and complement and description of the binding mechanism . J Exp Med . 1974;;140:877-894.
11 +
Zubler RH, Lange G, Lambert PH, Miescher PA.  Detection of immune complexes in unheated sera by a modified 125I Clq binding test . J Immunol . 1976;;116:232-235.
12 +
Hudson L, Hay FC. Practical Immunology . Boston, Mass: Blackwell Scientific Publications Inc; 1976;: chap 8 .
13 +
Bernstein LJ, Ochs HD, Wedgewood RJ, Rubinstein A.  Defective humoral immunity in pediatric acquired immune deficiency syndrome . J Pediatr . 1985;;107:352-357.
14 +
Espinoza LR, Osterland CK. Assays for Circulating Immune Complexes . New York, NY: Futura Publishing Co; 1983;:24.
15 +
Bender BS, Bohnsack JF, Sourlis SH, Frank MM, Quinn TC.  Demonstration of defective C3-receptor mediated clearance by the reticulo-endothelial system in patients with acquired immunodeficiency syndrome . JCI . 1987;;79:715-720.
16 +
Gupta S, Licorish K.  Circulating immune complexes in AIDS . N Engl J Med . 1984;;310:1530-1531.
17 +
Rubinstein A, Morecki R, Silverman B, et al.  Pulmonary disease in children with acquired immunodeficiency syndrome and AIDS-related complex . J Pediatr . 1986;;108:498-503.

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