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October 1990, Vol 144, No. 10 >
Article | October 1990

Transient Myeloproliferative Disorder of the Down Type in the Normal Newborn FREE

Derry Ridgway, MD; Gerda I. Benda, MD; Ellen Magenis, MD; Leland Allen; Gerald M. Segal, MD; Rita M. Braziel, MD; Robert C. Neerhout, MD
[+] Author Affiliations

Accepted for publication January 19, 1990.

Reprints not available.


Am J Dis Child. 1990;144(10):1117-1119. doi:10.1001/archpedi.1990.02150340063024.
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• TWo infants with congenital nonlymphoblastic leukemia were discovered to have mosaicism for trisomy 21. Both infants achieved durable spontaneous remissions. Trisomy was apparently restricted to the leukemic clone and could be detected in neither phytohemagglutinin-stimulated peripheral blood cells or bone marrow in either patient nor in myeloid progenitor cells from the second patient after resolution of the transient myeloproliferative disorder. We conclude that spontaneous remission of congenital leukemia is not confined to infants with partial or complete systemic trisomy 21 but can occur in genetically normal new-borns whose leukemic cells contain a third chromosome 21.

(AJDC. 1990;144:1117-1119)

REFERENCES

1 +
Schunk GL, Lehman WL.  Mongolism and congenital leukemia . JAMA . 1954;;155:250-251.
2 +
Granick DJ.  Hematological changes in Down's syndrome . Crit Rev Oncol Hematol . 1986;;6:55-69.
3 +
Van Eyes J, Flexner JM.  Transient spontaneous remission in a case of untreated congenital leukemia . AJDC . 1969;;118:507-510.
4 +
Lampkin BC, Peipon JJ, Price JK, Bove KE, Srivastava AK, Jones MM.  Spontaneous remission of presumed congenital acute nonlymphoblastic leukemia (ANLL) in a karyotypically normal neonate . Am J Pediatr Hematol Oncol . 1985;;7:346-351.
5 +
Weinberg AG, Schiller G, Windmiller J.  Neonatal leukemoid reaction: an isolated manifestation of trisomy 21 . AJDC . 1982;;136:310-311.
6 +
Heaton DC, Fitzgerald PH, Fraser GJ, Abbot GD.  Transient leukemoid proliferation of the cytogenetically unbalanced +21 cell line of a constitutional mosaic boy . Blood . 1981;;57:883-887.
7 +
Hanna MD, Melvin SL, Dow LW, Williams D, Dahl G, Mirro J.  Transient myeloproliferative syndrome in a phenotypically normal infant . Am J Pediatr Hematol Oncol . 1985;;7:79-81.
8 +
Seibel NL, Sommer A, Miser J.  Transient neonatal leukemoid reactions in mosaic trisomy 21 . J Pediatr . 1984;;104:251-254.
9 +
Brodeur GM, Dahl GV, Williams DL, Tipton RE, Kalwinsky DK.  Transient leukemoid reaction and trisomy 21 mosaicism in a phenotypically normal newborn . Blood . 1980;;55:691-693.
10 +
Ferster A, Verhest A, Vamos E, de Maertelaere E, Otten J.  Leukemia in a trisomy 21 mosaic: specific involvement of the trisomic cells . Cancer Genet Cytogenet . 1986;;20:109-113.
11 +
Waggoner DD. Origin of Human Trisomy 21 Mosaicism. Portland, Ore: Portland State University; 1984. Thesis.
12 +
Segal GM, McCall E, Bagby GC.  Erythroid burst-promoting activity produced by interleukin-1-stimulated endothelial cells is granulocyte-macrophage colony-stimulating factor . Blood . 1989;; 72:1364-1367.
13 +
Raskind WH, Disteche CM, Keating A, Singer JW.  Correlation between cytogenetic and molecular findings in human chronic myelogenous leukemia lines EM-2 and EM-3 . Cancer Genet Cytogenet . 1987;;25:271-284.
14 +
Rowley JD.  Down syndrome and acute leukemia: increased risk may be due to trisomy 21 . Lancet . 1980;;2:1020-1022.
15 +
Wong KY, Jones MM, Srivastava AK, Gruppa RA.  Transient myeloproliferative disorder and acute non-lymphoblastic leukemia in Down syndrome . J Pediatr . 1988;;112:18-22.

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References

1 +
Schunk GL, Lehman WL.  Mongolism and congenital leukemia . JAMA . 1954;;155:250-251.
2 +
Granick DJ.  Hematological changes in Down's syndrome . Crit Rev Oncol Hematol . 1986;;6:55-69.
3 +
Van Eyes J, Flexner JM.  Transient spontaneous remission in a case of untreated congenital leukemia . AJDC . 1969;;118:507-510.
4 +
Lampkin BC, Peipon JJ, Price JK, Bove KE, Srivastava AK, Jones MM.  Spontaneous remission of presumed congenital acute nonlymphoblastic leukemia (ANLL) in a karyotypically normal neonate . Am J Pediatr Hematol Oncol . 1985;;7:346-351.
5 +
Weinberg AG, Schiller G, Windmiller J.  Neonatal leukemoid reaction: an isolated manifestation of trisomy 21 . AJDC . 1982;;136:310-311.
6 +
Heaton DC, Fitzgerald PH, Fraser GJ, Abbot GD.  Transient leukemoid proliferation of the cytogenetically unbalanced +21 cell line of a constitutional mosaic boy . Blood . 1981;;57:883-887.
7 +
Hanna MD, Melvin SL, Dow LW, Williams D, Dahl G, Mirro J.  Transient myeloproliferative syndrome in a phenotypically normal infant . Am J Pediatr Hematol Oncol . 1985;;7:79-81.
8 +
Seibel NL, Sommer A, Miser J.  Transient neonatal leukemoid reactions in mosaic trisomy 21 . J Pediatr . 1984;;104:251-254.
9 +
Brodeur GM, Dahl GV, Williams DL, Tipton RE, Kalwinsky DK.  Transient leukemoid reaction and trisomy 21 mosaicism in a phenotypically normal newborn . Blood . 1980;;55:691-693.
10 +
Ferster A, Verhest A, Vamos E, de Maertelaere E, Otten J.  Leukemia in a trisomy 21 mosaic: specific involvement of the trisomic cells . Cancer Genet Cytogenet . 1986;;20:109-113.
11 +
Waggoner DD. Origin of Human Trisomy 21 Mosaicism. Portland, Ore: Portland State University; 1984. Thesis.
12 +
Segal GM, McCall E, Bagby GC.  Erythroid burst-promoting activity produced by interleukin-1-stimulated endothelial cells is granulocyte-macrophage colony-stimulating factor . Blood . 1989;; 72:1364-1367.
13 +
Raskind WH, Disteche CM, Keating A, Singer JW.  Correlation between cytogenetic and molecular findings in human chronic myelogenous leukemia lines EM-2 and EM-3 . Cancer Genet Cytogenet . 1987;;25:271-284.
14 +
Rowley JD.  Down syndrome and acute leukemia: increased risk may be due to trisomy 21 . Lancet . 1980;;2:1020-1022.
15 +
Wong KY, Jones MM, Srivastava AK, Gruppa RA.  Transient myeloproliferative disorder and acute non-lymphoblastic leukemia in Down syndrome . J Pediatr . 1988;;112:18-22.

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