0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Diagnosis, Incidence, and Prevention of Congenital Toxoplasmosis-Reply

MARJALEENA KOSKINIEMI, MD, PHD; MAIJA LAPPALAINEN, MD; KLAUS HEDMAN, MD
Am J Dis Child. 1990;144(9):957-958. doi:10.1001/archpedi.1990.02150330014009.
Text Size: A A A
Published online

In Reply.—We appreciate Dr Frenkel's interest in our review article, and thank him for explaining the details of the direct agglutination test.

The lack of correlation between titers and the severity of the disease is a property shared by all conventional antibody tests. To avoid iteration we mentioned it only once, in association with the standard Toxoplasma antibody assay, the Sabin-Feldman test.

Underdiagnosis of congenital toxoplasmosis is the rule in children of all age groups. During the perinatal period, false-negative IgM results are common1-3 and the IgG antibodies may be either of maternal origin or due to intrauterine infection. Differentiation between these two conditions is thus far impossible. When IgG antibodies are detected in children over 6 months of age, differentiation between the acquired and congenital infection is also impossible, irrespective of the country. An "intelligently applied test" could, in principle, be exemplified by IgG antibody assays run

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();