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Protective Efficacy of the Takeda Acellular Pertussis Vaccine Combined With Diphtheria and Tetanus Toxoids Following Household Exposure of Japanese Children

Edward A. Mortimer Jr, MD; Mikio Kimura, MD; James D. Cherry, MS, MD; Harumi Kuno-Sakai, MD; Mason G. Stout, MD, PhD; Cornelia L. Dekker, MD; Rika Hayashi, MS; Yoshio Miyamoto; Jane V. Scott, PhD; Tatsuo Aoyama, MD; Shin Isomura, MD; Takashi Iwata, MD; Hitoshi Kamiya, MD; Tatsuo Kato, MD; Junko Noya, MD; Eitaro Suzuki, MD; Yoshinao Takeuchi, MD; Hideki Yamaoka, MD
Am J Dis Child. 1990;144(8):899-904. doi:10.1001/archpedi.1990.02150320063029.
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• The clinical efficacy of an acellular pertussis vaccine containing lymphocytosis-promoting factor, filamentous hemagglutinin, agglutinogens, and the 69-kd outer membrane protein, combined with diphtheria and tetanus toxoids and adsorbed onto an aluminum salt, was assessed in a household contact study. The occurrence of pertussis 7 to 30 days following home exposure among 62 previously vaccinated children was compared with that among 62 unvaccinated children similarly exposed. Classic whooping cough was diagnosed in 43 unimmunized children, and 1 vaccinated child experienced a 5-week illness that was probably pertussis (efficacy, 98%; 95% confidence interval, 84% to 99%). A few children in each group incurred respiratory illnesses that may have represented mild, atypical pertussis; including these as probable pertussis, vaccine efficacy was 81% (95% confidence interval, 64% to 90%). It is concluded that prior immunization with this four-component pertussis vaccine combined with diphtheria and tetanus toxoids is highly efficacious in preventing pertussis.

(AJDC. 1990;144:899-904)

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