0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Neuromediated Myeloperoxidase Deficiency

PIETRO COCCHI, MD; CESARE COCCHI JR, MD
Am J Dis Child. 1990;144(7):746. doi:10.1001/archpedi.1990.02150310012004.
Text Size: A A A
Published online

Sir.—In the March 1925 issue of AJDC, Sato1 reported changes in the blood myeloid leukocytes, resulting from injuries to certain parts of the brain produced experimentally in animals. Only those rabbits that had received bilateral thermocautery lesions of the corpora striata showed a myeloperoxidase (MPO)–negative reaction of neutrophils in fresh blood smear stained by the copper method of Sato and Sekiya.2 A similar blood picture of transitory acquired MPO deficiency was described by Sato and Yoshimatsu2 in patients with acute lethargic encephalitis. These anecdotal observations2 were reported prior to the demonstration of an important immunologic role of this enzyme in the antimicrobial defense mechanism and the neural modulation of cellular immunity.

The neutrophils contain at least three different forms of MPO that may have special roles in cellular function.3 The MPO–hydrogen peroxide–halide system is believed to represent, however, a major pathway for oxidative-dependent microbicidal

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();