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Failure of Intravenous Gammaglobulin for Passive Immune Thrombocytopenia in a Neonate

Am J Dis Child. 1990;144(6):622. doi:10.1001/archpedi.1990.02150300016012.
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Sir.—Intravenous gammaglobulin (IVIG) therapy has been used with success in cases of neonatal thrombocytopenia caused by transplacentally transferred maternal autoantibodies1,2 and in neonatal isoimmune thrombocytopenia.3

Recently we reported a persistent increase in platelet count after 0.4 g/kg per day of intact polyethylene glycol–treated IVIG during the first 5 days of life in a neonate with immune thrombocytopenia, passively acquired from his mother.4

In another case, IVIG treatment was without benefit in a neonate with passive immune thrombocytopenia. In this case, the infant's mother had mild thrombocytopenia during the pregnancy (platelet count, 70 × 109/L). Her first child was noted to have thrombocytopenia at 2 months that spontaneously resolved after 2 months.

A male infant was born at term (gestational age, 39 weeks) by vaginal delivery to a woman with a normal pregnancy. His birth weight was 3740 g; Apgar scores were 9 at


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