We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Use of Angiotensin Converting Enzyme Inhibitors for the Treatment of Focal Segmental Glomerulosclerosis

Am J Dis Child. 1990;144(5):522. doi:10.1001/archpedi.1990.02150290016012.
Text Size: A A A
Published online

Sir.—Angiotensin converting enzyme (ACE) inhibitors have been shown to limit proteinuria and preserve renal function in adult patients with chronic renal insufficiency.1-4 Recent data by Trachtman and Gauthier5 demonstrated that short-term captopril therapy reduced urinary protein excretion in children with nephrotic range proteinuria of varying origins.

We reviewed charts of all patients less than 21 years of age who have been seen at The Children's Hospital of The Cleveland (Ohio) Clinic Foundation between January 1981 and October 1989 with a diagnosis of either nephrotic syndrome or asymptomatic proteinuria. Patients with biopsyproved focal segmental glomerulosclerosis were identified and categorized as having nephrotic syndrome as defined by the International Study of Kidney Disease in Children6 or proteinuria without the other manifestations of nephrotic syndrome. We chose this disease because of its resistance to usual therapy and progression to renal insufficiency. The following characteristics of the patients were analyzed:


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.