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January 1990, Vol 144, No. 1 >
Article | January 1990

Skin Testing Prior to Measles Vaccination for Egg-Sensitive Patients FREE

E. RICHARD STIEHM, MD
Am J Dis Child. 1990;144(1):32. doi:10.1001/archpedi.1990.02150250034026.
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The recrudescence of measles and the recommended reimmunization of older children1 spotlights the problem of measles vaccination for the egg-sensitive patient. Measles vaccine (and mumps vaccine) is grown in chick embryo cell culture (not embryonated eggs), so there is a very low, but detectable, presence of egg-related antigens in the vaccine. In this issue of the AJDC, Dr Andrew Kemp and associates2 from Sydney, Australia, suggest that despite a history of immediate hypersensitivity reactions to egg protein, measles vaccine can be given safely without performing a vaccine skin test.3 Kemp et al make his recommendation based on the following facts:

  1. They immunized 32 children with a history of egg sensitivity without performing skin tests and observed no adverse reactions.

  2. A certain percentage of allergic children (5% to 10%) will react to the vaccine skin test (particularly children with eczema); most of these children can receive

REFERENCES

1 +
Brunell PA.  Measles vaccine: one or two doses? Pediatrics . 1988;;81:722-723.
2 +
Kemp A, Van Asperen P, Mukhi A.  Measles immunization in children with clinical reactions to egg protein . AJDC . 1990;;144:33-35.
3 +
American Academy of Pediatrics. Report of the Committee of Infectious Diseases (Red Book) . Elk Grove Village, Ill: American Academy of Pediatrics Publications; 1988;.
4 +
Juntunen-Backman K, Peltola H, Backman A, Salo OP.  Safe immunization of allergic children against measles, mumps, and rubella . AJDC . 1987;;141:1103-1105.
5 +
Aukrust L, Almeland TL, Refsum D, Aas K.  Severe hypersensitivity or intolerance reactions to measles vaccine in six children . Allergy . 1980;;35:581-587.
6 +
Herman JJ, Radin R, Schneiderman R.  Allergic reactions to measles (rubeola) vaccine in patients hypersensitive to egg protein . J Pediatr . 1983;;102:196-199.
7 +
Greenberg MA, Birx DL.  Safe administration of mumps-measles-rubella vaccine in egg-allergic children . J Pediatr . 1988;;113:504-506.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

1 +
Brunell PA.  Measles vaccine: one or two doses? Pediatrics . 1988;;81:722-723.
2 +
Kemp A, Van Asperen P, Mukhi A.  Measles immunization in children with clinical reactions to egg protein . AJDC . 1990;;144:33-35.
3 +
American Academy of Pediatrics. Report of the Committee of Infectious Diseases (Red Book) . Elk Grove Village, Ill: American Academy of Pediatrics Publications; 1988;.
4 +
Juntunen-Backman K, Peltola H, Backman A, Salo OP.  Safe immunization of allergic children against measles, mumps, and rubella . AJDC . 1987;;141:1103-1105.
5 +
Aukrust L, Almeland TL, Refsum D, Aas K.  Severe hypersensitivity or intolerance reactions to measles vaccine in six children . Allergy . 1980;;35:581-587.
6 +
Herman JJ, Radin R, Schneiderman R.  Allergic reactions to measles (rubeola) vaccine in patients hypersensitive to egg protein . J Pediatr . 1983;;102:196-199.
7 +
Greenberg MA, Birx DL.  Safe administration of mumps-measles-rubella vaccine in egg-allergic children . J Pediatr . 1988;;113:504-506.

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