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Prolactinoma in a Prepubescent Girl

Am J Dis Child. 1990;144(1):20. doi:10.1001/archpedi.1990.02150250022019.
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To the Editor.—The report by Tiwary1 in the May 1989 issue of AJDC of a case of prolactinoma in an adolescent girl is an important addition to the literature on prolactinoma in adolescents. Many clinicians believe that these tumors occur only after pubescence has begun and endogenous estrogen is increased. The author stated that the youngest described patient of whom she is aware is a 13-year-old girl. I would like to bring to the attention of your readers a report by Cheyne et al2 describing a bromocriptine-unresponsive prolactin macroadenoma in a prepubescent girl, 11 years 10 months old. The symptoms actually began at age 8½ years. A transsphenoidal surgical excision was performed 8 months after the initiation of bromocriptine therapy. The authors recommended that a minimum 6-month trial of bromocriptine therapy be used. Because of the locally invasive nature of the adenoma, radiation therapy was used as


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