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Down Syndrome and 3,3′,5′-Triiodothyronine

JÉRÔME LEJEUNE, MD, PHD; MARIE PEETERS, MD; MARIE ODILE RETHORE, MD; MARIE CHRISTINE DE BLOIS, MD; JEAN PIERRE DEVAUX, MD
Am J Dis Child. 1990;144(1):19. doi:10.1001/archpedi.1990.02150250021017.
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Sir.—Since publications cross geographic but only rarely linguistic boundaries, we wish to bring to your attention our recent publication on elevated thyrotropin (TSH) levels and Down syndrome (DS).1

Our findings are in accordance with those observed by Sharav et al.2

A prospective survey was carried out on 78 patients with DS (age range, 6 months to 16 years; mean, 9.08±6.99 years) followed up at our genetics clinic, Hopital des Enfants Malades, Paris, France. The TSH levels were significantly elevated (t = 9.5; P<<<.001) in the group with trisomy 21 (3.99±2.54 mU/L) as compared with 214 age-matched normal children (2.01±0.85 mU/L). There was no difference in free thyroxine (T4) levels between both groups (trisomy 21, 20.55±3.81 pmol/L; controls, 21.12±3.19 pmol/L). Free triiodothyronine (T3) levels, however, tended to be lower in the DS group (7.09±1.68 pmol/L) vs controls (7.92±1.39 pmol/L) (t=2.4; P=.05).

We observed a

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