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Transmission of Chickenpox in a School Setting Prior to the Observed Exanthem FREE

Philip A. Brunell, MD
[+] Author Affiliations

Accepted for publication July 14, 1989.

Reprint requests to Ahmanson Pediatric Center, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048 (Dr Brunell).


Am J Dis Child. 1989;143(12):1451-1452. doi:10.1001/archpedi.1989.02150240073020.
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• An epidemic of chickenpox in a class is described. Four children were able to transmit infection prior to the time their rash was observed by their parents. A fifth child was known to have attended school while he had localized varicelliform lesions that were present for 2 days prior to the appearance of the generalized exanthem. It cannot be ascertained whether some of the other children may have had similar lesions that were not observed at the time they attended school. The first classroom case was observed prospectively so that the time of rash was fairly well established. Although he apparently transmitted infection prior to the onset of rash, virus could not be isolated from the respiratory secretion of this child on the day he presumably infected his classmate. Virus was not found in his respiratory secretions or those obtained from his two siblings before or after the onset of rash, although it was recovered from vesicular fluid.

(AJDC. 1989;143:1451-1452)

REFERENCES

 Chickenpox (varicella) and herpes zoster . In: Peter G, ed. Report of the Committee on the Control of Infectious Diseases . 21st ed. Elk Grove Village, Ill: American Academy of Pediatrics; 1988;:456-462.
Enders JF, Peebles TC.  Propagation of tissue cultures of cytopathic agents from patients with measles . Proc Soc Exp Biol Med. 1954;;86:277-286.
Brunell PA, Brickman A, O'Hare D, Steinberg S.  Ineffectiveness of isolation of patients as a method of preventing the spread of mumps . N Engl J Med. 1968;;279:1357-1361.
Gold E.  Serologic and virus-isolation studies of patients with varicella or herpes-zoster infection . N Engl JMed . 1966;;274:181-185.
Cesario TC, Kriel RL, Caldwell GG, Davis LE, Chin TDY.  Epidemiologic observations of virus infections in a closed population of young children . Am J Epidemiol . 1971;;94:457-466.
Nelson AM, St Geme JR Jr.  On the respiratory spread of varicella-zoster virus . Pediatrics . 1966;;37:1007-1009.
Trlifajova J, Bryndova D, Ryc M.  Isolation of varicella-zoster virus from pharyngeal and nasal swabs in varicella patients . J Hyg Epidemiol Microbiol Immunol . 1984;;28:201-206.
Ozaki T, Yashiharu M, Asano Y, Okuno T, Yamanishi K, Takahashi M. Study of virus isolation from pharyngeal swabs in children with varicella. AJDC. In press.
Bierman HR, Crile DM, Dod KS, et al.  Remissions in leukemia of childhood following acute infectious disease . Cancer . 1953;;6:591-605.
Gordon JE, Meader FM.  The period of infectivity and serum prevention of chickenpox . JAMA . 1929;;93:2013-2015.
Evans P.  An epidemic of chickenpox . Lancet . 1940;;2:339-340.
Ross AH.  Modification of chickenpox in family contacts by adminstration of gamma globulin . N Engl J Med . 1962;;267:369-376.
Brunell PA.  Infections in day-care centers . AJDC . 1987;;141:404-405.
Preblud SR.  Varicella: complications and costs . Pediatrics . 1986;;78:4:728-743.

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References

 Chickenpox (varicella) and herpes zoster . In: Peter G, ed. Report of the Committee on the Control of Infectious Diseases . 21st ed. Elk Grove Village, Ill: American Academy of Pediatrics; 1988;:456-462.
Enders JF, Peebles TC.  Propagation of tissue cultures of cytopathic agents from patients with measles . Proc Soc Exp Biol Med. 1954;;86:277-286.
Brunell PA, Brickman A, O'Hare D, Steinberg S.  Ineffectiveness of isolation of patients as a method of preventing the spread of mumps . N Engl J Med. 1968;;279:1357-1361.
Gold E.  Serologic and virus-isolation studies of patients with varicella or herpes-zoster infection . N Engl JMed . 1966;;274:181-185.
Cesario TC, Kriel RL, Caldwell GG, Davis LE, Chin TDY.  Epidemiologic observations of virus infections in a closed population of young children . Am J Epidemiol . 1971;;94:457-466.
Nelson AM, St Geme JR Jr.  On the respiratory spread of varicella-zoster virus . Pediatrics . 1966;;37:1007-1009.
Trlifajova J, Bryndova D, Ryc M.  Isolation of varicella-zoster virus from pharyngeal and nasal swabs in varicella patients . J Hyg Epidemiol Microbiol Immunol . 1984;;28:201-206.
Ozaki T, Yashiharu M, Asano Y, Okuno T, Yamanishi K, Takahashi M. Study of virus isolation from pharyngeal swabs in children with varicella. AJDC. In press.
Bierman HR, Crile DM, Dod KS, et al.  Remissions in leukemia of childhood following acute infectious disease . Cancer . 1953;;6:591-605.
Gordon JE, Meader FM.  The period of infectivity and serum prevention of chickenpox . JAMA . 1929;;93:2013-2015.
Evans P.  An epidemic of chickenpox . Lancet . 1940;;2:339-340.
Ross AH.  Modification of chickenpox in family contacts by adminstration of gamma globulin . N Engl J Med . 1962;;267:369-376.
Brunell PA.  Infections in day-care centers . AJDC . 1987;;141:404-405.
Preblud SR.  Varicella: complications and costs . Pediatrics . 1986;;78:4:728-743.

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