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October 1989, Vol 143, No. 10 >
Article | October 1989

Hirschsprung's Disease and Ocular Autonomic Nerve Function FREE

G. O'CONNOR, MB, DO, FRCS, FCOPHTH; A. HOOPER, DBOD; L. BECK, MB, DO, FRCS, FCOPHTH; J. LARI, DCH, FRCS
[+] Author Affiliations

We thank Timothy Peters, BSC, MSc, PhD, for his statistical advice.


Am J Dis Child. 1989;143(10):1137. doi:10.1001/archpedi.1989.02150220025012.
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Sir.—We pharmacologically assessed the ocular autonomic nervous systems of 10 children with Hirschsprung's disease, using 0.1% pilocarpine nitrate and 0.5% phenylephrine hydrochloride. Our results did not indicate any significant abnormality in the ocular autonomic nervous systems of children with Hirschsprung's disease, compared with those of normal controls.

Hirschsprung's disease is a congenital anomaly of innervation affecting the intrinsic plexuses of Auerbach and Meissner in the lower gut.1 These autonomic plexuses are derived from the craniocervical neural crest.2 The superior cervical ganglion (sympathetic) and the ciliary ganglion (parasympathetic) of the eye are also derived from the craniocervical neural crest.3

Patients and Methods.—Ten children with Hirschsprung's disease, two girls and eight boys, between 4 and 14 years of age were examined. All children had histologically proved Hirschsprung's disease. Twenty age- and sex-matched controls were obtained from our pediatric ophthalmology screening clinics.

Baseline measurements included visual acuity, orthoptic

REFERENCES

1 +
Whitehouse FR, Kernohan JW.  Myenteric plexus in congenital megacolon . Arch Intern Med . 1948;;82:75-79.
2 +
Okamoto E, Ueda T.  Embryogenesis of the intramural ganglia of the gut and its relation to Hirschsprung's disease . J Pediatr Surg . 1967;;2: 437-443.
3 +
Bolande RP.  The neurocristopathies: a unifying concept of disease arising in neural crest maldevelopment . Hum Pathol . 1974;;5:409-429.
4 +
Miller NR. Walsh and Hoyt's Clinical Neuro-Ophthalmology . Baltimore, Md: Williams & Wilkins; 1985;.
5 +
Meire F, Strandaert L, Zeng LH.  Waardenberg syndrome, Hirschsprung megacolon and Marcus-Gunn ptosis . Am J Med Genet . 1987;; 27:683-686.
6 +
Cannon WB, Rosenbluth A. The Supersensitivity of Denervated Structures: a Law of Denervation . New York, NY: Macmillan Publishing Co Inc; 1949;.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

1 +
Whitehouse FR, Kernohan JW.  Myenteric plexus in congenital megacolon . Arch Intern Med . 1948;;82:75-79.
2 +
Okamoto E, Ueda T.  Embryogenesis of the intramural ganglia of the gut and its relation to Hirschsprung's disease . J Pediatr Surg . 1967;;2: 437-443.
3 +
Bolande RP.  The neurocristopathies: a unifying concept of disease arising in neural crest maldevelopment . Hum Pathol . 1974;;5:409-429.
4 +
Miller NR. Walsh and Hoyt's Clinical Neuro-Ophthalmology . Baltimore, Md: Williams & Wilkins; 1985;.
5 +
Meire F, Strandaert L, Zeng LH.  Waardenberg syndrome, Hirschsprung megacolon and Marcus-Gunn ptosis . Am J Med Genet . 1987;; 27:683-686.
6 +
Cannon WB, Rosenbluth A. The Supersensitivity of Denervated Structures: a Law of Denervation . New York, NY: Macmillan Publishing Co Inc; 1949;.

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