Sir.—To my knowledge, this instance of collagenous colitis in a 7-year-old boy is the first to be documented in a child. This condition is of unknown etiology and, in this case, appeared to respond to
Stained sections from a rectal biopsy specimen showing the normal surface epithelium, the deposition of collagen as a band beneath the basement membrane, and the sparse chronic inflammatory infiltrate within the lamina propria (hematoxylin-eosin, original magnification × 140 [left] and ×320 [right]). sulfasalazine therapy. Since the original description by Lindstrom1 in 1976 of the clinicopathologic syndrome that was labeled collagenous colitis, about 50 patients2,3 with this condition have been described, all adults.
Patient Report.—A 7-year-old boy had complained of large-volume watery diarrhea for several months; there were up to 10 bowel movements per day. Fasting and/or milk abstinence failed to improve the diarrhea. The feces contained no mucus or blood, and