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September 1989, Vol 143, No. 9 >
Article | September 1989

Twice-Daily Therapy for Strep?-Reply FREE

MICHAEL A. GERBER, MD
Am J Dis Child. 1989;143(9):997. doi:10.1001/archpedi.1989.02150210013003.
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In Reply.—In the conclusion of our article,1 we attempted to make a distinction between our recommendations and those of the AHA. As Dr Gill has correctly observed, the AHA does not list twice-daily penicillin therapy as an acceptable regimen for the treatment of streptococcal pharyngitis.2 However, based on our findings3 and those of several other investigators,4-8 we believe that twice-daily penicillin V therapy is an effective regimen. The Committee on Infectious Diseases of the American Academy of Pediatrics also notes that "with good compliance, two doses of oral pencillin totaling 800,000 U (500 mg) daily have been reported to be effective."9

REFERENCES

1 +
Gerber MA, Randolph MF, DeMeo K, Feder HM Jr, Kaplan EL.  Failure of once-daily penicillin V therapy for streptococcal pharyngitis . AJDC . 1989;;143:153-155.
2 +
Dajani AS, Bisno AL, Chung KJ, et al.  Prevention of rheumatic fever: a statement for health professionals by the Committee on Rheumatic Fever, Infective Endocarditis, and Kawasaki Disease of the Council on Cardiovascular Disease in the Young . Circulation . 1988;;78:1082-1086.
3 +
Gerber MA, Spadaccini LJ, Wright LL, Deutsch L, Kaplan EL.  Twice-daily penicillin in the treatment of streptococcal pharyngitis . AJDC . 1985;;110:125-130.
4 +
Breese BB, Disney FA, Talpey WB.  Penicillin in streptococcal infections: total dose and frequency of administration . AJDC . 1965;;110: 125-130.
5 +
Rosenstein RJ, Markowitz M, Goldstein E, et al.  Factors involved in treatment failures following oral penicillin for streptococcal pharyngitis . J Pediatr . 1968;;73:513-520.
6 +
Vann RL, Harris BA.  Twice-a-day penicillin for streptococcal upper respiratory infections . South Med J . 1972;;65:203-205.
7 +
Stillerman M, Isenberg HD, Facklam RR.  Streptococcal pharyngitis therapy: comparison of clindamycin palmitate and potassium phenoxymethyl penicillin . Antimicrob Agents Chemother . 1973;;4:514-520.
8 +
Spitzer TQ, Harris BA.  Penicillin V therapy for streptococcal pharyngitis: comparison of dosage schedules . South Med J . 1977;;70:41-42.
9 +
Peter G, Hall CB, Lepow ML, Phillips CF, eds: Report of the Committee on Infectious Diseases . 21st ed. Elk Grove, Ill: American Academy of Pediatrics; 1988;:391.

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References

1 +
Gerber MA, Randolph MF, DeMeo K, Feder HM Jr, Kaplan EL.  Failure of once-daily penicillin V therapy for streptococcal pharyngitis . AJDC . 1989;;143:153-155.
2 +
Dajani AS, Bisno AL, Chung KJ, et al.  Prevention of rheumatic fever: a statement for health professionals by the Committee on Rheumatic Fever, Infective Endocarditis, and Kawasaki Disease of the Council on Cardiovascular Disease in the Young . Circulation . 1988;;78:1082-1086.
3 +
Gerber MA, Spadaccini LJ, Wright LL, Deutsch L, Kaplan EL.  Twice-daily penicillin in the treatment of streptococcal pharyngitis . AJDC . 1985;;110:125-130.
4 +
Breese BB, Disney FA, Talpey WB.  Penicillin in streptococcal infections: total dose and frequency of administration . AJDC . 1965;;110: 125-130.
5 +
Rosenstein RJ, Markowitz M, Goldstein E, et al.  Factors involved in treatment failures following oral penicillin for streptococcal pharyngitis . J Pediatr . 1968;;73:513-520.
6 +
Vann RL, Harris BA.  Twice-a-day penicillin for streptococcal upper respiratory infections . South Med J . 1972;;65:203-205.
7 +
Stillerman M, Isenberg HD, Facklam RR.  Streptococcal pharyngitis therapy: comparison of clindamycin palmitate and potassium phenoxymethyl penicillin . Antimicrob Agents Chemother . 1973;;4:514-520.
8 +
Spitzer TQ, Harris BA.  Penicillin V therapy for streptococcal pharyngitis: comparison of dosage schedules . South Med J . 1977;;70:41-42.
9 +
Peter G, Hall CB, Lepow ML, Phillips CF, eds: Report of the Committee on Infectious Diseases . 21st ed. Elk Grove, Ill: American Academy of Pediatrics; 1988;:391.

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