In Reply.—Chiesa et al and Oderda et al agree with us regarding the high prevalence of CP infection and its relationship to antral gastritis and duodenal ulcer.
The highly effective results of antimicrobial therapy reported by Chiesa et al are interesting. To date, we have en unsuccessful in eradicating CP with amoxicillin monotherapy. Our results are in agreement with recently reported adult studies by Rauws et al,1 as well as pediatric studies by De Giacomo et al.2 The latter group had no success in eradicating CP or improving the underlying gastritis in their pediatric patients. The experience cited above by Oderda et al also indicates failure to achieve permanent eradication of the organism with ampicillin. We look forward to the publication of the study done by Chiesa et al. Perhaps we may be able to determine why we and others have not been successful in our efforts to eradicate