0
June 1989, Vol 143, No. 6 >
Article | June 1989

Growth Response of Growth Hormone-Deficient Patients to 0.06 mg/kg Compared With 0.10 mg/kg Three Times per Week of Biosynthetic Growth Hormone

ARLAN L. ROSENBLOOM, MD; CAROLE L. KNUTH, PA-C
Am J Dis Child. 1989;143(6):642-643. doi:10.1001/archpedi.1989.02150180020008.
Text Size: A A A
Published online
Article
References
Comments

Sir.—The optimal dosage of growth hormone (GH) for the treatment of GH deficiency has not been determined. As little as 2.5 U given once weekly can result in catch-up growth.1 Raben2 established a dosage of 2 U three times per week regardless of body size as the standard that was used into the 1980s. In a series of reports the US Collaborative Study Group concluded that a dosage of 0.06 U/kg of body weight three times per week was appropriate. These and other studies were summarized by Frasier3 in a comprehensive review. He developed a log-dose response curve, based on the published data, that had a very shallow slope, indicating a decreasing cost benefit of increasing dosage.

The purpose of this study was to compare what had been a relatively high dosage of pituitary extract GH (0.12 U or 0.06 mg/kg three times per week) recommended by one manufacturer

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

Correspondence

Submit a Letter
CME
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Clear Answers | Save For Later
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s “Cited By” API will populate this tab (http://www.crossref.org/citedby.html).
Compression-Only CPR: Pushing the Science Forward
Cone
AAM 2010;304:1493-1495.
All you need to read in the other general journals
BMJ 2010;341:c5893-c1494.
Submit a Comment

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs

More Listings at
JAMACareerCenter.com >

© 2013 American Medical Association. All Rights Reserved.
Powered bySilverchair Information Systems