Parent-Child Minimal Change Nephrotic Syndrome

Sir.—Choi et al¹ reported the occurrence of nephrotic syndrome in a father and daughter. The parent and child developed the nephrotic syndrome at 22 and 8 years of age, respectively. The father had biopsyproved minimal change nephrotic syndrome and his daughter was presumed to have the same lesion, based on her clinical presentation and response to prednisone therapy. Choi et al also cited a report by White² of another father and daughter with steroid-responsive nephrotic syndrome.

We are aware of another occurrence of minimal change nephrotic syndrome in a parent and child. In 1979, Schwartz and Cornfeld³ reported a case of a mother and son who had relapsing steroid-responsive nephrotic syndrome. The mother's brother also developed the nephrotic syndrome. The mother and brother developed the nephrotic syndrome at ages 8 and 12 years, respectively. They both had a renal biopsy specimen demonstrating minimal glomerular changes. The