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Article |

Chlamydia and the Adolescent Girl:  The Enzyme Immunoassay as a Screening Tool

Karen Soren, MD; Earnestine Willis, MD, MPH
Am J Dis Child. 1989;143(1):51-54. doi:10.1001/archpedi.1989.02150130061015.
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• To evaluate the enzyme immunoassay for Chlamydia detection in a population of sexually active urban adolescent girls, 100 endocervical screens using both immunoassay and tissue cell culture were performed. Prevalence of Chlamydia trachomatis was 35%, with more than two thirds of infected adolescents being asymptomatic. When compared with cell culture, the immunoassay was determined to have a sensitivity of 74%, a specificity of 98%, and positive and negative predictive values of 96% and 88%, respectively. Adolescents with false-negative immunoassay test results were more likely to lack evidence of cervical inflammation on examination and have lower-titer infections than their peers with positive results. When the immunoassay was matched against culture for test of cure after therapy, a 10% false-positive rate was found. We conclude that the immunoassay is a useful screening technique for detection of Chlamydia in high-risk adolescent populations; however, its limitations with respect to decreased sensitivity in asymptomatic girls and poor positive predictive value in the context of tests of cure must be appreciated.

(AJDC 1989;143:51-54)

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