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January 1989, Vol 143, No. 1 >
Article | January 1989

Immunization After Invasive Haemophilus influenzae Type b Disease:  Serologic Response to a Conjugate Vaccine FREE

Kathryn M. Edwards, MD; Michael D. Decker, MD, MPH; Carol R. Porch, MD; Pamela Palmer, MS; Roberta Bradley, MSN
[+] Author Affiliations

Accepted for publication Aug 16, 1988.

Reprint requests to Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, TN 37232 (Dr Edwards).


Am J Dis Child. 1989;143(1):31-33. doi:10.1001/archpedi.1989.02150130041012.
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References
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• Fifteen children with previous invasive Haemophilus influenzae type b disease were immunized with a Hemophilus-diphtheria toxin mutant protein conjugate vaccine. Serologic responses were compared with those of 31 newly immunized children without previous invasive H influenzae type b disease. Mean levels of antibody to polyribosylribitol phosphate among study children younger than 18 months were 0.086 mg/L before immunization, 0.737 mg/L after first immunization, and 4.453 mg/L after second immunization. In contrast, the comparable mean polyribosylribitol phosphate antibody levels among control children younger than 18 months were 0.107, 3.580, and 63.502 mg/L. A similar pattern of results was found among children aged 18 months or older. Although children with previous invasive H influenzae type b disease do not respond as vigorously to conjugate vaccine as do previously healthy controls, the response is sufficient to justify routine immunization of such children.

(AJDC 1989;143:31-33)

REFERENCES

1 +
Peltola H, Kayhty H, Virtanen M, et al:  Prevention of Hemophilus influenzae type b bacteremic infections with the capsular polysaccharide vaccine . N Engl J Med 1984;;310:1561-1566.
2 +
Smith DH, Peter G, Ingram DL, et al:  Responses of children immunized with the capsular polysaccharide of Haemophilus influenzae type b . Pediatrics 1973;;52:637-645.
3 +
Norden C, Michaels R, Melish M:  Serologic responses of children with meningitis due to Haemophilus influenzae type b . J Infect Dis 1976;;134:195-199.
4 +
Edmondson MB, Granoff D, Barenkamp S, et al:  Outer membrane protein subtypes and investigation of recurrent Haemophilus influenzae type b disease . J Pediatr 1982;;100:202-208.
5 +
Norden C, Michaels R, Melsih H:  Effect of previous infection on antibody response of children to vaccination with capsular polysaccharide of Haemophilus influenzae type b . J Infect Dis 1975;;132:69-74.
6 +
Lepow M, Samuelson J, Gordon L:  Safety and immunogenicity of Haemophilus influenzae type b–polysaccharide diphtheria toxoid conjugate vaccine in infants 9 to 15 months of age . J Pediatr 1985;;106:185-189.
7 +
Anderson P, Pichichero M, Insel R:  Immunization of 2-month old infants with protein coupled oligosaccharides derived from the capsule of Haemophilus influenzae type b . J Pediatr 1985;;107:346-351.
8 +
Anderson P, Pichichero M, Edwards K, et al:  Priming and induction of Haemophilus influenzae type b capsular antibodies in early infancy by Dpo20, an oligosaccharide-protein conjugate vaccine . J Pediatr 1987;;111:644-650.
9 +
Eskola J, Peltola H, Takala AK, et al:  Efficacy of Haemophilus influenzae type b polysaccharide–diphtheria toxoid conjugate vaccine in infancy . N Engl J Med 1987;;317:716-722.
10 +
Einhorn MS, Weinberg GA, Anderson EL, et al:  Immunogenicity in infants of Haemophilus influenzae type b polysaccharide in a conjugate vaccine with Neisseria meningitidis outer-membrane protein . Lancet 1986;;2:299-302.
11 +
Weinberg GA, Einhorn MS, Lenoir AA, et al:  Immunologic priming to capsular polysaccharide in infants immunized with Haemophilus influenzae type b polysaccharide–Neisseria meningitidis outer membrane protein conjugate vaccine . J Pediatr 1987;;111:22-27.
12 +
American Academy of Pediatrics, Committee on Infectious Diseases:  Revision of recommendation for use of rifampin prophylaxis of contacts of patients with Haemophilus influenzae infection . Pediatrics 1984;;74:301-302.
13 +
Anderson P, Pichichero ME, Insel RA:  Immunogens consisting of oligosaccharides from the capsule of Haemophilus influenzae type b coupled to diphtheria toxoid or CRM 197 . J Clin Invest 1985;;76:52-59.
14 +
Anderson P:  Intrinsic tritium labeling of the capsular polysaccharide antigen of Haemophilus influenzae type b . J Immunol 1978;; 120:866-870.
15 +
Armitage P: Statistical Methods in Medical Research . New York, John Wiley & Sons Inc, 1971;, pp 442-456.
16 +
White C: Statistical methods in serum surveys , in Paul JR, White C (eds): Serologic Epidemiology. Orlando, Fla, Academic Press Inc, 1973;, pp 19-32.
17 +
Colton T: Statistics in Medicine . Boston, Little Brown & Co Inc, 1974;, pp 131-142.
18 +
Fothergill LD, Wright J:  Influenzal meningitis: The relation of age incidence to the bactericidal power of the blood against the causal organism . J Immunol 1933;;24:273-284.
19 +
Anderson P, Insel R, Farsad R, et al:  Immunogenicity of 'aggregated PRP,' 'PRP-complex,' and covalent conjugates of PRP with a diphtheria toxoid , in Sell SH, Wright PF (eds): Haemophilus influenzae: Epidemiology, Immunology, and Prevention of Disease . New York, Elsevier Science Publishing Co Inc, 1982;, pp 275-284.
20 +
Recommendations of the immunization practices advisory committee (ACIP):  Update: Prevention of Haemophilus influenzae type b disease . MMWR 1988;;37:13-16.

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References

1 +
Peltola H, Kayhty H, Virtanen M, et al:  Prevention of Hemophilus influenzae type b bacteremic infections with the capsular polysaccharide vaccine . N Engl J Med 1984;;310:1561-1566.
2 +
Smith DH, Peter G, Ingram DL, et al:  Responses of children immunized with the capsular polysaccharide of Haemophilus influenzae type b . Pediatrics 1973;;52:637-645.
3 +
Norden C, Michaels R, Melish M:  Serologic responses of children with meningitis due to Haemophilus influenzae type b . J Infect Dis 1976;;134:195-199.
4 +
Edmondson MB, Granoff D, Barenkamp S, et al:  Outer membrane protein subtypes and investigation of recurrent Haemophilus influenzae type b disease . J Pediatr 1982;;100:202-208.
5 +
Norden C, Michaels R, Melsih H:  Effect of previous infection on antibody response of children to vaccination with capsular polysaccharide of Haemophilus influenzae type b . J Infect Dis 1975;;132:69-74.
6 +
Lepow M, Samuelson J, Gordon L:  Safety and immunogenicity of Haemophilus influenzae type b–polysaccharide diphtheria toxoid conjugate vaccine in infants 9 to 15 months of age . J Pediatr 1985;;106:185-189.
7 +
Anderson P, Pichichero M, Insel R:  Immunization of 2-month old infants with protein coupled oligosaccharides derived from the capsule of Haemophilus influenzae type b . J Pediatr 1985;;107:346-351.
8 +
Anderson P, Pichichero M, Edwards K, et al:  Priming and induction of Haemophilus influenzae type b capsular antibodies in early infancy by Dpo20, an oligosaccharide-protein conjugate vaccine . J Pediatr 1987;;111:644-650.
9 +
Eskola J, Peltola H, Takala AK, et al:  Efficacy of Haemophilus influenzae type b polysaccharide–diphtheria toxoid conjugate vaccine in infancy . N Engl J Med 1987;;317:716-722.
10 +
Einhorn MS, Weinberg GA, Anderson EL, et al:  Immunogenicity in infants of Haemophilus influenzae type b polysaccharide in a conjugate vaccine with Neisseria meningitidis outer-membrane protein . Lancet 1986;;2:299-302.
11 +
Weinberg GA, Einhorn MS, Lenoir AA, et al:  Immunologic priming to capsular polysaccharide in infants immunized with Haemophilus influenzae type b polysaccharide–Neisseria meningitidis outer membrane protein conjugate vaccine . J Pediatr 1987;;111:22-27.
12 +
American Academy of Pediatrics, Committee on Infectious Diseases:  Revision of recommendation for use of rifampin prophylaxis of contacts of patients with Haemophilus influenzae infection . Pediatrics 1984;;74:301-302.
13 +
Anderson P, Pichichero ME, Insel RA:  Immunogens consisting of oligosaccharides from the capsule of Haemophilus influenzae type b coupled to diphtheria toxoid or CRM 197 . J Clin Invest 1985;;76:52-59.
14 +
Anderson P:  Intrinsic tritium labeling of the capsular polysaccharide antigen of Haemophilus influenzae type b . J Immunol 1978;; 120:866-870.
15 +
Armitage P: Statistical Methods in Medical Research . New York, John Wiley & Sons Inc, 1971;, pp 442-456.
16 +
White C: Statistical methods in serum surveys , in Paul JR, White C (eds): Serologic Epidemiology. Orlando, Fla, Academic Press Inc, 1973;, pp 19-32.
17 +
Colton T: Statistics in Medicine . Boston, Little Brown & Co Inc, 1974;, pp 131-142.
18 +
Fothergill LD, Wright J:  Influenzal meningitis: The relation of age incidence to the bactericidal power of the blood against the causal organism . J Immunol 1933;;24:273-284.
19 +
Anderson P, Insel R, Farsad R, et al:  Immunogenicity of 'aggregated PRP,' 'PRP-complex,' and covalent conjugates of PRP with a diphtheria toxoid , in Sell SH, Wright PF (eds): Haemophilus influenzae: Epidemiology, Immunology, and Prevention of Disease . New York, Elsevier Science Publishing Co Inc, 1982;, pp 275-284.
20 +
Recommendations of the immunization practices advisory committee (ACIP):  Update: Prevention of Haemophilus influenzae type b disease . MMWR 1988;;37:13-16.

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