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December 1988, Vol 142, No. 12 >
Article | December 1988

Increased Cytosol Aminopeptidase and Lactate Dehydrogenase in Serum Originating From Lymphocytes in Measles and Rubella Infection FREE

Norio Sugaya, MD; Mari Nirasawa, MD; Keiko Mitamura, MD; Yoshinao Takeuchi, MD; Mitsuru Osano, MD; Takashi Kanno, MD
[+] Author Affiliations

Accepted for publication Aug 10, 1988.

Reprint requests to Department of Pediatrics, Nippon Kokan Hospital, 1-2-1 Kokandori, Kawasaki-ku, Kawasaki, Kanagawa, Japan (Dr Sugaya).


Am J Dis Child. 1988;142(12):1352-1355. doi:10.1001/archpedi.1988.02150120106051.
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References
Comments

• We determined cytosol aminopeptidase (c-AP; EC 3.4.11.1) and lactate dehydrogenase (LDH) levels in serum; these enzymes are known to originate from lymphocytes in patients with measles and rubella. In patients with measles (n=19), both enzyme levels increased markedly with the onset of rash: mean (±SD) c-AP was 269.7± 103.5 U/L and LDH was 1149.5±255.2 U/L. In patients with rubella, activities of both enzymes increased mildly: c-AP (n=18) was 81.6 ± 24.4 U/L and LDH (n = 13) was 674.0±168.8 U/L. Increased c-AP and LDH levels in patients with measles and rubella presumably originate from the destruction of infected, activated lymphocytes, especially T lymphocytes.

(AJDC 1988;142:1352-1355)

REFERENCES

1 +
Sugaya N, Takeuchi Y, Kanno T:  Increased lactate dehydrogenase in serum in measles infection . Clin Chem 1987;;33:661-663.
2 +
Sugaya N, Takeuchi Y, Kanno T:  Increased cytosol aminopeptidase in serum in measles infection . Clin Chem 1988;;34:212-213.
3 +
Wróblewski F, Gregory KF:  Lactic dehydrogenase isozymes and their distribution in normal tissues and plasma and in disease states . Ann NY Acad Sci 1961;;94:912-932.
4 +
Ringoir S, Plum J:  LDH isozymes of human T and B lymphocytes . Clin Chim Acta 1975;;60: 379-383.
5 +
Blatt J, Spiegel RJ, Papadopoulos NM, et al:  Lactate dehydrogenase isoenzymes in normal and malignant human lymphoid cells . Blood 1982;;60:491-494.
6 +
Csako G, Magrath IT, Elin RJ:  Serum total and isoenzyme lactate dehydrogenase activity in American Burkitt's lymphoma patients . Am J Clin Pathol 1982;;78:712-717.
7 +
Silverman B, Rubinstein A:  Serum lactate dehydrogenase levels in adults and children with acquired immune deficiency syndrome and AIDS-related complex: Possible indicator of B cell lymphoproliferation and disease activity . Am J Med 1985;;78:728-736.
8 +
Rubinstein A, Morecki R, Silverman B, et al:  Pulmonary disease in children with acquired immune deficiency syndrome and AIDS-related complex . J Pediatr 1986;;108:498-503.
9 +
Kanno T, Maekawa M, Kanda S, et al:  Evaluation of cytosolic aminopeptidase in human sera: Evaluation in hepatic disorders . Am J Clin Pathol 1984;;82:700-705.
10 +
Kohno H, Kanno T:  Properties and activities of aminopeptidases in normal and mitogenstimulated human lymphocytes . Biochem J 1985;;226:59-65.
11 +
Saito M, Takegoshi T, Aoyagi H, et al:  Stimulatory effect of bestatin, a new specific inhibitor of aminopeptidases, on the blastogenesis of guinea pig lymphocytes . Cell Immunol 1978;;40:247-262.
12 +
Fischer H, Hambsch K, Reinelt S, et al:  Die Serumaktivitat der Leuzinaminopeptidase bei lymphotropen Infektionen und malignen Lymphomen . Z Gesamte Inn Med 1979;;34:392-394.
13 +
Hayashi M, Tokuhiro H, Kuto F, et al:  Leucine amide specific LAP activity in hematological and lymphogenous disorders . Rinsho Ketsueki 1983;;24:507-516.
14 +
Sugaya N, Nirasawa M, Takeuchi Y, et al:  Hepatitis in acquired rubella infection in children . AJDC 1988;;142:817-818.
15 +
Sugiyama M, Tamura S, Hirate F, et al:  The method using leucine amide as substrate for the continuous monitoring analysis of leucine aminopeptidase . Jpn J Clin Chem 1980;;9:313-320.
16 +
Wróblewski F, LaDue JS:  Lactic dehydrogenase activity in blood . Proc Soc Exp Biol Med 1955;;90:210-213.
17 +
Henry RJ, Chiamori N, Golub OJ, et al:  Revised spectrophotometric methods for the determination of glutamic oxaloacetic transaminase, glutamic pyruvic transaminase and lactic dehydrogenase . Am J Clin Pathol 1960;;34:381-398.
18 +
Chantler JK, Tingle AJ:  Isolation of rubella virus from human lymphocytes after acute natural infection . J Infect Dis 1982;;145:673-677.
19 +
Horstmann DM:  Rubella , in Evans AS (ed): Viral Infections of Humans , ed 2. New York, Plenum Medical Book Co, 1982;, pp 519-538.
20 +
Rogers PA, Brenton DP, Hopkinson DA:  Changes in activity and isozyme patterns of glycolytic enzymes during stimulation of normal human lymphocytes with phytohaemagglutinin . Ann Hum Genet 1980;;43:213-226.
21 +
Kohno H, Kanno T:  Properties and activities of aminopeptidases in normal and mitogen-stimulated human lymphocytes . Biochem J 1985;;226:59-65.
22 +
Gallagher MR, Flanagan TD:  Replication of measles virus in continuous lymphoid cell lines . J Immunol 1976;;116:1084-1088.
23 +
Valdimarsson H, Agnarsdottir G, Lachmann PJ:  Measles virus receptor on human T cells . Nature 1975;;225:554-556.

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References

1 +
Sugaya N, Takeuchi Y, Kanno T:  Increased lactate dehydrogenase in serum in measles infection . Clin Chem 1987;;33:661-663.
2 +
Sugaya N, Takeuchi Y, Kanno T:  Increased cytosol aminopeptidase in serum in measles infection . Clin Chem 1988;;34:212-213.
3 +
Wróblewski F, Gregory KF:  Lactic dehydrogenase isozymes and their distribution in normal tissues and plasma and in disease states . Ann NY Acad Sci 1961;;94:912-932.
4 +
Ringoir S, Plum J:  LDH isozymes of human T and B lymphocytes . Clin Chim Acta 1975;;60: 379-383.
5 +
Blatt J, Spiegel RJ, Papadopoulos NM, et al:  Lactate dehydrogenase isoenzymes in normal and malignant human lymphoid cells . Blood 1982;;60:491-494.
6 +
Csako G, Magrath IT, Elin RJ:  Serum total and isoenzyme lactate dehydrogenase activity in American Burkitt's lymphoma patients . Am J Clin Pathol 1982;;78:712-717.
7 +
Silverman B, Rubinstein A:  Serum lactate dehydrogenase levels in adults and children with acquired immune deficiency syndrome and AIDS-related complex: Possible indicator of B cell lymphoproliferation and disease activity . Am J Med 1985;;78:728-736.
8 +
Rubinstein A, Morecki R, Silverman B, et al:  Pulmonary disease in children with acquired immune deficiency syndrome and AIDS-related complex . J Pediatr 1986;;108:498-503.
9 +
Kanno T, Maekawa M, Kanda S, et al:  Evaluation of cytosolic aminopeptidase in human sera: Evaluation in hepatic disorders . Am J Clin Pathol 1984;;82:700-705.
10 +
Kohno H, Kanno T:  Properties and activities of aminopeptidases in normal and mitogenstimulated human lymphocytes . Biochem J 1985;;226:59-65.
11 +
Saito M, Takegoshi T, Aoyagi H, et al:  Stimulatory effect of bestatin, a new specific inhibitor of aminopeptidases, on the blastogenesis of guinea pig lymphocytes . Cell Immunol 1978;;40:247-262.
12 +
Fischer H, Hambsch K, Reinelt S, et al:  Die Serumaktivitat der Leuzinaminopeptidase bei lymphotropen Infektionen und malignen Lymphomen . Z Gesamte Inn Med 1979;;34:392-394.
13 +
Hayashi M, Tokuhiro H, Kuto F, et al:  Leucine amide specific LAP activity in hematological and lymphogenous disorders . Rinsho Ketsueki 1983;;24:507-516.
14 +
Sugaya N, Nirasawa M, Takeuchi Y, et al:  Hepatitis in acquired rubella infection in children . AJDC 1988;;142:817-818.
15 +
Sugiyama M, Tamura S, Hirate F, et al:  The method using leucine amide as substrate for the continuous monitoring analysis of leucine aminopeptidase . Jpn J Clin Chem 1980;;9:313-320.
16 +
Wróblewski F, LaDue JS:  Lactic dehydrogenase activity in blood . Proc Soc Exp Biol Med 1955;;90:210-213.
17 +
Henry RJ, Chiamori N, Golub OJ, et al:  Revised spectrophotometric methods for the determination of glutamic oxaloacetic transaminase, glutamic pyruvic transaminase and lactic dehydrogenase . Am J Clin Pathol 1960;;34:381-398.
18 +
Chantler JK, Tingle AJ:  Isolation of rubella virus from human lymphocytes after acute natural infection . J Infect Dis 1982;;145:673-677.
19 +
Horstmann DM:  Rubella , in Evans AS (ed): Viral Infections of Humans , ed 2. New York, Plenum Medical Book Co, 1982;, pp 519-538.
20 +
Rogers PA, Brenton DP, Hopkinson DA:  Changes in activity and isozyme patterns of glycolytic enzymes during stimulation of normal human lymphocytes with phytohaemagglutinin . Ann Hum Genet 1980;;43:213-226.
21 +
Kohno H, Kanno T:  Properties and activities of aminopeptidases in normal and mitogen-stimulated human lymphocytes . Biochem J 1985;;226:59-65.
22 +
Gallagher MR, Flanagan TD:  Replication of measles virus in continuous lymphoid cell lines . J Immunol 1976;;116:1084-1088.
23 +
Valdimarsson H, Agnarsdottir G, Lachmann PJ:  Measles virus receptor on human T cells . Nature 1975;;225:554-556.

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