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Increased Cytosol Aminopeptidase and Lactate Dehydrogenase in Serum Originating From Lymphocytes in Measles and Rubella Infection

Norio Sugaya, MD; Mari Nirasawa, MD; Keiko Mitamura, MD; Yoshinao Takeuchi, MD; Mitsuru Osano, MD; Takashi Kanno, MD
Am J Dis Child. 1988;142(12):1352-1355. doi:10.1001/archpedi.1988.02150120106051.
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• We determined cytosol aminopeptidase (c-AP; EC and lactate dehydrogenase (LDH) levels in serum; these enzymes are known to originate from lymphocytes in patients with measles and rubella. In patients with measles (n=19), both enzyme levels increased markedly with the onset of rash: mean (±SD) c-AP was 269.7± 103.5 U/L and LDH was 1149.5±255.2 U/L. In patients with rubella, activities of both enzymes increased mildly: c-AP (n=18) was 81.6 ± 24.4 U/L and LDH (n = 13) was 674.0±168.8 U/L. Increased c-AP and LDH levels in patients with measles and rubella presumably originate from the destruction of infected, activated lymphocytes, especially T lymphocytes.

(AJDC 1988;142:1352-1355)


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