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Relation of Bone Mineralization Measures to Serum Biochemical Measures

STEVEN A. ABRAMS, MD; RICHARD J. SCHANLER, MD; CUTBERTO GARZA, MD, PHD
Am J Dis Child. 1988;142(12):1276. doi:10.1001/archpedi.1988.02150120030028.
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Sir.—Harkavy1 discussed the theoretical benefits of reporting bone mineral content (BMC) measurements (mg/cm) in terms of their relation to bone width (BW) or a derivative of BW. This argument is in keeping with the results of studies in adults that suggest that correction of BMC for bone size may be useful in evaluating bone mineralization.2 This view is challenged by Vyhmeister and colleagues,3 who state that the division of BMC by BW or a derivative of it (such as BW2) may add additional errors to the estimate of bone mineralization. We suggest that although both Harkavy and Vyhmeister et al present well-developed theoretical arguments, neither position is supported by new bone mineral data.

Although no absolute method has been identified as the ideal measure by which to determine bone mineralization in infants, the relative utility of different measures of bone mineralization may be established by

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