Article |

Efficacy of Leuprolide Therapy in Children With Central Precocious Puberty

Michael S. Kappy, MD, PhD; Thomas Stuart, RN, BSN; Alvin Perelman, MD
Am J Dis Child. 1988;142(10):1061-1064. doi:10.1001/archpedi.1988.02150100055025.
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• Eight girls with central precocious puberty were treated with the long-acting gonadotropin releasing hormone analogue leuprolide acetate (Lupron) for a period of six to 18 months. Suppression of gonadotropin and estradiol secretion and regression of secondary sexual characteristics and menses were observed while patients received a subcutaneous dose of 35 to 40 μg/kg/d. Growth velocity was slowed in all but one patient, and the rate of skeletal maturation was slowed even more, resulting in a stabilization or improvement in predicted adult height. There were no major side effects. Although the long-term effects of leuprolide therapy cannot be determined with this study, it appears to be efficacious in the treatment of central precocious puberty.

(AJDC 1988;142:1061-1064)


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