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Neurodevelopmental and Respiratory Outcome in Early Childhood After Human Surfactant Treatment FREE

Yvonne E. Vaucher, MD; T. Allen Merritt, MD; Mikko Hallman, MD; Anna-Liisa Jarvenpaa, MD; Aimee M. Telsey, MD; Barbara L. Jones, RN, MN, CPNP
[+] Author Affiliations

Accepted for publication June 2, 1988.

Reprint requests to UCSD Medical Center, H-814-J, Department of Pediatrics, Division of Neonatology, 225 W Dickinson, San Diego, CA 92103 (Dr Vaucher).


Am J Dis Child. 1988;142(9):927-930. doi:10.1001/archpedi.1988.02150090025015.
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• We assessed postnatal growth, neurodevelopmental outcome, and occurrence of respiratory illnesses In 46 infants of very low birth weight who were enrolled in a randomized, controlled, bicenter clinical trial of human surfactant treatment for respiratory distress syndrome. No long-term adverse effects of human surfactant treatment were detected between control and human surfactant–treated infants with respect to growth, neurologic, or developmental outcome. Infants with chronic lung disease, regardless of treatment group, had poorer growth and were more likely to have neurodevelopmental abnormalities at 12 to 24 months of age.

(AJDC 1988;142:927-930)

REFERENCES

Hallman M, Merritt TA, Jarvenpaa AL, et al:  Exogenous human surfactant for treatment of severe respiratory distress syndrome: A randomized prospective clinical trial . J Pediatr 1985;;106:963-969.
Link to Article
Merritt TA, Hallman M, Bloom BT, et al:  Prophylactic treatment of very premature infants with human surfactant . N Engl J Med 1986;; 315:785-790.
Link to Article
Taeusch HW, Clements J, Benson B:  Exogenous surfactant for human lung disease . Am Rev Respir Dis 1983;;128:791-794.
Toce SS, Farrell PM, Leavitt LA, et al:  Clinical and roentgenographic scoring systems for assessing bronchopulmonary dysplasia . AJDC 1984;;138:581-585.
Hamill PVV, Drizd TA, Johnson CL, et al:  Physical growth: National Center for Health Statistics percentiles . Am J Clin Nutr 1979;; 32:607-629.
Papile LA, Munsick-Bruno G, Schaefer A:  Relationship of cerebral intraventricular hemorrhage and early childhood neurologic handicaps . J Pediatr 1983;;103:273-277.
Link to Article
Enhorning GE, Shennan A, Possmayer F, et al:  Prevention of neonatal respiratory distress syndrome by tracheal instillation of surfactant: A randomized clinical trial . Pediatrics 1985;; 76:145-153.
Kwong MS, Egan EA, Notter RH, et al:  A double-blind clinical trial of calf lung lipid for the prevention of hyaline membrane disease in extremely premature infants . Pediatrics 1985;; 76:585-592.
Shapiro DL, Notter RH, Morin FC, et al:  A double-blind, randomized trial of a calf lung surfactant extract administered at birth to very premature infants for prevention of the respiratory distress syndrome . Pediatrics 1985;;76:593-599.
Gatlin JD, Sell RF, Parad RB, et al:  Randomized controlled trial of exogenous surfactant for the treatment of hyaline membrane disease . Pediatrics 1987;;79:31-37.
Raju T, Bhat R, McCullock K, et al:  Double-blind control trial of single-dose treatment with bovine surfactant in severe hyaline membrane disease . Lancet 1987;;1:651-656.
Link to Article
Ware J, Parad R, Soll R, et al:  Developmental outcome following surfactant treatment of RDS . Pediatr Res 1986;;20:368A.
Dunn MS, Shennan AT, Hoskins EM, et al:  Two-year follow-up on infants enrolled in a randomized trial of surfactant supplementation , abstracted. Pediatr Res 1987;;21:359A.
Halliday HL, McClure G, Reide M:  Growth and development two years after artificial surfactant replacement at birth . Early Hum Dev 1986;;113:323-327.
Link to Article
Merritt TA, Vaucher YE:  Infant follow-up programs: Their impact on infants and families . Dev Behav Pediatr 1987;;8:286-287.
Field TM, Dempsey JR, Ting GT, et al:  Respiratory distress syndrome: Perinatal prediction of one year developmental outcome . Semin Perinatol 1982;;6:288-293.
Yu VY, Downe L, Astbury J, et al:  Perinatal factors and adverse outcome in extremely low birth weight infants . Arch Dis Child 1986;;61:554-558.
Link to Article
Ross G, Schechner S, Frayer WW, et al:  Perinatal and neurobehavioral predictors of one year outcome in infants ≤1500 grams . Semin Perinatol 1982;;6:317-326.
Wallace IF, Escalona SK, McCarton-Daum C, et al:  Neonatal precursors of cognitive development in low birth weight children . Semin Perinatol 1982;;6:327-333.
Cohen SE, Sigman M, Parmelee AH, et al:  Perinatal risk and developmental outcome in preterm infants . Semin Perinatol 1982;;6:334-337.
Sell EJ, Vaucher YE:  Growth and developmental outcome , in Merritt TA, Boynton B, Northway W (eds): Bronchopulmonary Dysplasia . Boston, Blackwell Scientific Publications Inc, 1988;, pp 403-420.
Goldson E:  Severe bronchopulmonary dysplasia in the very low birth weight infant: Its relationship to developmental outcome . J Devel Behav Pediatr 1984;;5:165-168.
Vohr BR, Bell EF, Oh W:  Infants with bronchopulmonary dysplasia: Growth pattern and neurologic and developmental outcome . AJDC 1982;;136:443-447.
Meisels SJ, Plunkett JW, Roloff DW, et al:  Growth and development of preterm infants with respiratory distress syndrome and bronchopulmonary dysplasia . Pediatrics 1986;;77:345-352.
Strayer DS, Merritt TA, Lwebuga-Muskaa J, et al:  Surfactant-anti-surfactant immune complexes in infants with respiratory distress syndrome . Am J Pathol 1986;;122:353-362.
Hull WM, Whitsett JA:  Immunologic analysis of infants receiving surfactant . Pediatr Res 1988;;23:1257.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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References

Hallman M, Merritt TA, Jarvenpaa AL, et al:  Exogenous human surfactant for treatment of severe respiratory distress syndrome: A randomized prospective clinical trial . J Pediatr 1985;;106:963-969.
Link to Article
Merritt TA, Hallman M, Bloom BT, et al:  Prophylactic treatment of very premature infants with human surfactant . N Engl J Med 1986;; 315:785-790.
Link to Article
Taeusch HW, Clements J, Benson B:  Exogenous surfactant for human lung disease . Am Rev Respir Dis 1983;;128:791-794.
Toce SS, Farrell PM, Leavitt LA, et al:  Clinical and roentgenographic scoring systems for assessing bronchopulmonary dysplasia . AJDC 1984;;138:581-585.
Hamill PVV, Drizd TA, Johnson CL, et al:  Physical growth: National Center for Health Statistics percentiles . Am J Clin Nutr 1979;; 32:607-629.
Papile LA, Munsick-Bruno G, Schaefer A:  Relationship of cerebral intraventricular hemorrhage and early childhood neurologic handicaps . J Pediatr 1983;;103:273-277.
Link to Article
Enhorning GE, Shennan A, Possmayer F, et al:  Prevention of neonatal respiratory distress syndrome by tracheal instillation of surfactant: A randomized clinical trial . Pediatrics 1985;; 76:145-153.
Kwong MS, Egan EA, Notter RH, et al:  A double-blind clinical trial of calf lung lipid for the prevention of hyaline membrane disease in extremely premature infants . Pediatrics 1985;; 76:585-592.
Shapiro DL, Notter RH, Morin FC, et al:  A double-blind, randomized trial of a calf lung surfactant extract administered at birth to very premature infants for prevention of the respiratory distress syndrome . Pediatrics 1985;;76:593-599.
Gatlin JD, Sell RF, Parad RB, et al:  Randomized controlled trial of exogenous surfactant for the treatment of hyaline membrane disease . Pediatrics 1987;;79:31-37.
Raju T, Bhat R, McCullock K, et al:  Double-blind control trial of single-dose treatment with bovine surfactant in severe hyaline membrane disease . Lancet 1987;;1:651-656.
Link to Article
Ware J, Parad R, Soll R, et al:  Developmental outcome following surfactant treatment of RDS . Pediatr Res 1986;;20:368A.
Dunn MS, Shennan AT, Hoskins EM, et al:  Two-year follow-up on infants enrolled in a randomized trial of surfactant supplementation , abstracted. Pediatr Res 1987;;21:359A.
Halliday HL, McClure G, Reide M:  Growth and development two years after artificial surfactant replacement at birth . Early Hum Dev 1986;;113:323-327.
Link to Article
Merritt TA, Vaucher YE:  Infant follow-up programs: Their impact on infants and families . Dev Behav Pediatr 1987;;8:286-287.
Field TM, Dempsey JR, Ting GT, et al:  Respiratory distress syndrome: Perinatal prediction of one year developmental outcome . Semin Perinatol 1982;;6:288-293.
Yu VY, Downe L, Astbury J, et al:  Perinatal factors and adverse outcome in extremely low birth weight infants . Arch Dis Child 1986;;61:554-558.
Link to Article
Ross G, Schechner S, Frayer WW, et al:  Perinatal and neurobehavioral predictors of one year outcome in infants ≤1500 grams . Semin Perinatol 1982;;6:317-326.
Wallace IF, Escalona SK, McCarton-Daum C, et al:  Neonatal precursors of cognitive development in low birth weight children . Semin Perinatol 1982;;6:327-333.
Cohen SE, Sigman M, Parmelee AH, et al:  Perinatal risk and developmental outcome in preterm infants . Semin Perinatol 1982;;6:334-337.
Sell EJ, Vaucher YE:  Growth and developmental outcome , in Merritt TA, Boynton B, Northway W (eds): Bronchopulmonary Dysplasia . Boston, Blackwell Scientific Publications Inc, 1988;, pp 403-420.
Goldson E:  Severe bronchopulmonary dysplasia in the very low birth weight infant: Its relationship to developmental outcome . J Devel Behav Pediatr 1984;;5:165-168.
Vohr BR, Bell EF, Oh W:  Infants with bronchopulmonary dysplasia: Growth pattern and neurologic and developmental outcome . AJDC 1982;;136:443-447.
Meisels SJ, Plunkett JW, Roloff DW, et al:  Growth and development of preterm infants with respiratory distress syndrome and bronchopulmonary dysplasia . Pediatrics 1986;;77:345-352.
Strayer DS, Merritt TA, Lwebuga-Muskaa J, et al:  Surfactant-anti-surfactant immune complexes in infants with respiratory distress syndrome . Am J Pathol 1986;;122:353-362.
Hull WM, Whitsett JA:  Immunologic analysis of infants receiving surfactant . Pediatr Res 1988;;23:1257.

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