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May 1988, Vol 142, No. 5 >
Article | May 1988

Infantile Myofibromatosis and the Use of Magnetic Resonance Imaging FREE

THOMAS E. WISWELL, MD
Am J Dis Child. 1988;142(5):486. doi:10.1001/archpedi.1988.02150050024020.
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Sir.—I read the recent report of Moore et al1 with a great deal of interest. These authors described the use of magnetic resonance imaging (MRI) to evaluate and follow the course of an infant with "congenital generalized fibromatosis." My colleagues and I2,3 have recently reviewed the disorder in more than 170 infants, and I wish to make several comments. The condition is more aptly termed infantile myofibromatosis (IM).2-5 Approximately half of affected infants will have solitary rather than multiple lesions. In addition, 25% of the children will present after the neonatal period. Finally, the term infantile myofibromatosis emphasizes the dual histopathologic features of the lesions—characteristics of both smooth muscle and fibroblasts.

Infantile myofibromatosis represents the most common fibrous tumor of infancy. In contrast to Moore and colleagues' statement, involvement of IM in the central nervous system has been reported.4,6,7 Approximately one third of infants with

REFERENCES

1 +
Moore JB, Waldenmaier N, Potchen EJ:  Congenital generalized fibromatosis: A new management strategy provided by magnetic resonance imaging . AJDC 1987;;141:714-716.
2 +
Wiswell TE, Sakas EL, Stephenson SR, et al:  Infantile myofibromatosis . Pediatrics 1985;; 76:981-984.
3 +
Wiswell TE, Davis J, Cunningham BE, et al: Infantile myofibromatosis: The most common fibrous tumor of infancy. J Pediatr Surg, in press.
4 +
Chung EB, Enzinger FM:  Infantile myofibromatosis . Cancer 1981;;48:1807-1818.
5 +
Enzinger FM, Weiss SW: Soft Tissue Tumors . St Louis, CV Mosby Co, 1983;, pp 78-83.
6 +
Dimmick JE, Wood WS:  Congenital multiple fibromatosis . Am J Dermatopathol 1983;;5: 289-295.
7 +
Altemani AM, Amstalden EI, Filho JM:  Congenital generalized fibromatosis causing spinal cord compression . Hum Pathol 1985;;16:1063-1065.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

1 +
Moore JB, Waldenmaier N, Potchen EJ:  Congenital generalized fibromatosis: A new management strategy provided by magnetic resonance imaging . AJDC 1987;;141:714-716.
2 +
Wiswell TE, Sakas EL, Stephenson SR, et al:  Infantile myofibromatosis . Pediatrics 1985;; 76:981-984.
3 +
Wiswell TE, Davis J, Cunningham BE, et al: Infantile myofibromatosis: The most common fibrous tumor of infancy. J Pediatr Surg, in press.
4 +
Chung EB, Enzinger FM:  Infantile myofibromatosis . Cancer 1981;;48:1807-1818.
5 +
Enzinger FM, Weiss SW: Soft Tissue Tumors . St Louis, CV Mosby Co, 1983;, pp 78-83.
6 +
Dimmick JE, Wood WS:  Congenital multiple fibromatosis . Am J Dermatopathol 1983;;5: 289-295.
7 +
Altemani AM, Amstalden EI, Filho JM:  Congenital generalized fibromatosis causing spinal cord compression . Hum Pathol 1985;;16:1063-1065.

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