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Infantile Myofibromatosis and the Use of Magnetic Resonance Imaging

THOMAS E. WISWELL, MD
Am J Dis Child. 1988;142(5):486. doi:10.1001/archpedi.1988.02150050024020.
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Sir.—I read the recent report of Moore et al1 with a great deal of interest. These authors described the use of magnetic resonance imaging (MRI) to evaluate and follow the course of an infant with "congenital generalized fibromatosis." My colleagues and I2,3 have recently reviewed the disorder in more than 170 infants, and I wish to make several comments. The condition is more aptly termed infantile myofibromatosis (IM).2-5 Approximately half of affected infants will have solitary rather than multiple lesions. In addition, 25% of the children will present after the neonatal period. Finally, the term infantile myofibromatosis emphasizes the dual histopathologic features of the lesions—characteristics of both smooth muscle and fibroblasts.

Infantile myofibromatosis represents the most common fibrous tumor of infancy. In contrast to Moore and colleagues' statement, involvement of IM in the central nervous system has been reported.4,6,7 Approximately one third of infants with

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