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March 1988, Vol 142, No. 3 >
Article | March 1988

Antibody Response of Children to Measles Vaccine Mixed With Diphtheria-Pertussis-Tetanus or Diphtheria-Pertussis-Tetanus-Poliomyelitis Vaccine FREE

Eric A. F. Simoes; Vinohar Balraj, MD; R. Selvakumar, MVSc; T. Jacob John, FRCP, PhD
[+] Author Affiliations

Accepted for publication Oct 26, 1987.

Reprint requests to Department of Virology, Christian Medical College Hospital, Vellore, Tamilnadu 632 004 India (Dr John).


Am J Dis Child. 1988;142(3):309-311. doi:10.1001/archpedi.1988.02150030083026.
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References
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• The feasibility of giving measles vaccine mixed with either diphtheria-pertussis-tetanus (DPT) or DPT-poliomyelitis (DPTP) vaccine was investigated to simplify the routine Immunization schedule. Children 12 to 18 months of age, due for measles immunization, were given measles vaccine alone or mixed with DPT or DPTP. Their prevaccinatlon and four-weeks postvaccination serum samples were tested for the measles virus hemagglutination-inhibition antibody titer. Although 191 children completed the study, only 160 were initially seronegative. The seroconversion rates and geometric mean antibody titers in children given measles vaccine alone, mixed with DPT, or mixed with DPTP were 98%, 96.3%, and 96.4% and 41, 53, and 53, respectively. Local and systemic reactions were no more frequent in children given the mixture of vaccines than in children given DPTP alone. In summary, injecting measles vaccine mixed with DPT or DPTP did not diminish its immunogenic potency or increase adverse reactions. We believe that freshly mixed measles and DPT or DPTP vaccines can be given together, thus avoiding two separate injections.

(AJDC 1988;142:309-311)

REFERENCES

1 +
Simoes EAF, Padmini B, Steinhoff MC, et al:  Antibody response of infants to two doses of inactivated poliovirus vaccine of enhanced potency . AJDC 1985;;139:977-980.
2 +
John TJ, Selvakumar R:  Mixing measles vaccine with DPT and DPTP . Lancet 1985;;1:1154.
3 +
John TJ, Selvakumar R, Simoes EAF, et al:  Antibody response to measles vaccine given mixed with DPTP . AJDC 1987;;141:14.
4 +
Gershon AA, Krugman S:  Measles virus , in Lennette EH, Schmidt NJ (eds): Diagnostic Procedures for Viral, Rickettsial and Chlamydial Infections , ed 5. Washington, DC, American Public Health Association Inc, 1979;, pp 665-693.
5 +
Reuben FL, Smith EA, Foster SO, et al:  Simultaneous administration of smallpox, measles, yellow fever and diphtheria-pertussis-tetanus antigens to Nigerian children . Bull WHO 1973;;48:175-181.
6 +
Marshall R, Habicht JP, Landrigan PJ, et al:  Effectiveness of measles vaccine given simultaneously with DPT . J Trop Pediatr 1974;;20: 126-129.
7 +
McBean AM, Gateff C, Manclark CR, et al:  Simultaneous administration of live attenuated measles vaccine with DPT vaccine . Pediatrics 1978;;62:288-293.
8 +
McIntyre RC, Preblud SR, Polloi A, et al:  Measles and measles vaccine efficacy in a remote island population . Bull WHO 1982;;60:767-775.
9 +
Merieux C, Triau R, Ajjan N, et al:  Vaccination quintuple: Association du vaccin rougeole hyperattenue (Schwarz) avec le vaccin antidiphtherique, antitetanique, anticoquelucheux absorb et antipoliomyelitique inactive . Rev Pediatr 1973;;9:79-84.
10 +
John TJ, Joseph A, George TI, et al:  Epidemiology and prevention of measles in rural south India . Indian J Med Res 1980;;72:153-158.
11 +
Cherian T, Joseph A, John TJ:  Low antibody response in infants with measles and children with subclinical virus infection . J Trop Med Hyg 1984;;87:27-31.
12 +
John TJ, Jesudoss ES:  A survey of measles antibody in children . Indian J Pediatr 1973;;10: 65-66.
13 +
Mangay-Angara A, Fulgencio L, Casabal G, et al:  A two-dose schedule for immunization of infants using a more concentrated DPT vaccine . Dev Biol Stand 1978;;41:15-22.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

1 +
Simoes EAF, Padmini B, Steinhoff MC, et al:  Antibody response of infants to two doses of inactivated poliovirus vaccine of enhanced potency . AJDC 1985;;139:977-980.
2 +
John TJ, Selvakumar R:  Mixing measles vaccine with DPT and DPTP . Lancet 1985;;1:1154.
3 +
John TJ, Selvakumar R, Simoes EAF, et al:  Antibody response to measles vaccine given mixed with DPTP . AJDC 1987;;141:14.
4 +
Gershon AA, Krugman S:  Measles virus , in Lennette EH, Schmidt NJ (eds): Diagnostic Procedures for Viral, Rickettsial and Chlamydial Infections , ed 5. Washington, DC, American Public Health Association Inc, 1979;, pp 665-693.
5 +
Reuben FL, Smith EA, Foster SO, et al:  Simultaneous administration of smallpox, measles, yellow fever and diphtheria-pertussis-tetanus antigens to Nigerian children . Bull WHO 1973;;48:175-181.
6 +
Marshall R, Habicht JP, Landrigan PJ, et al:  Effectiveness of measles vaccine given simultaneously with DPT . J Trop Pediatr 1974;;20: 126-129.
7 +
McBean AM, Gateff C, Manclark CR, et al:  Simultaneous administration of live attenuated measles vaccine with DPT vaccine . Pediatrics 1978;;62:288-293.
8 +
McIntyre RC, Preblud SR, Polloi A, et al:  Measles and measles vaccine efficacy in a remote island population . Bull WHO 1982;;60:767-775.
9 +
Merieux C, Triau R, Ajjan N, et al:  Vaccination quintuple: Association du vaccin rougeole hyperattenue (Schwarz) avec le vaccin antidiphtherique, antitetanique, anticoquelucheux absorb et antipoliomyelitique inactive . Rev Pediatr 1973;;9:79-84.
10 +
John TJ, Joseph A, George TI, et al:  Epidemiology and prevention of measles in rural south India . Indian J Med Res 1980;;72:153-158.
11 +
Cherian T, Joseph A, John TJ:  Low antibody response in infants with measles and children with subclinical virus infection . J Trop Med Hyg 1984;;87:27-31.
12 +
John TJ, Jesudoss ES:  A survey of measles antibody in children . Indian J Pediatr 1973;;10: 65-66.
13 +
Mangay-Angara A, Fulgencio L, Casabal G, et al:  A two-dose schedule for immunization of infants using a more concentrated DPT vaccine . Dev Biol Stand 1978;;41:15-22.

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