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Reversible True Precocious Puberty Secondary to a Congenital Arachnoid Cyst

SUSAN J. CLARK, MD; CORNELIS VAN DOP, MD, PHD; FELIX A. CONTE, MD; MELVIN M. GRUMBACH, MD; MITCHELL S. BERGER, MD; MICHAEL S. B. EDWARDS, MD
Am J Dis Child. 1988;142(3):255-256. doi:10.1001/archpedi.1988.02150030021011.
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Sir.—True precocious puberty associated with arachnoid cysts has been reported previously. We studied a female infant, aged 2 years 9 months, with central precocious puberty and a large congenital arachnoid cyst in the middle cranial fossa. The elevated gonadotropin and estradiol levels and the precocious sexual development regressed following neurosurgical decompression of the arachnoid cyst.

Patient Report.—A female infant had been born to a 22-year-old mother at term by cesarean section necessitated by cephalopelvic disproportion. The Apgar score was 8 at one minute and 9 at five minutes. Birth weight was 3.38 kg (75th percentile); length, 52 cm (90th percentile); and head circumference, 34 cm (50th percentile). Development was normal. She had several generalized seizures associated with fever.

At 2 years 9 months of age, she was referred to the Pediatric Endocrinology Clinic at the University of California, San Francisco, for evaluation of breast development and one episode

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