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Pneumocystis carinii Serologic Study in Pediatric Acquired Immunodeficiency Syndrome

Linda L. Williford Pifer, PhD; Diane R. Woods; Carol C. Edwards; Rebecca E. Joyner, MT; Frank J. Anderson; Kris Arheart
Am J Dis Child. 1988;142(1):36-39. doi:10.1001/archpedi.1988.02150010046018.
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Pneumocystis carinii antigen and IgG antibody profiles were prepared on 17 pediatric patients with acquired immunodeficiency syndrome (AIDS) with pneumonia who were examined by a variety of invasive methods for P carinii organisms. Overall, the accuracy of the antigen assay in invasively examined pediatric patients with AIDS with pneumonia was 94% (sensitivity, 100%; specificity, 90%), as antigen and invasive test results agreed in 16 of 17 patients. No statistically significant differences in IgG titer were observed between controls and patients invasively examined for P carinii, whether the organism was observed in the specimen or not. Since 38% of all serum samples referred were derived from "blood-borne" cases of AIDS, including patients who contracted AIDS as a result of both transfusion and hemophilia A, this suggests that P carinii pneumonia or P carinii pneumonia—like pneumonias may be more common in these individuals.

(AJDC 1988;142:36-39)

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