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January 1988, Vol 142, No. 1 >
Article | January 1988

Pneumocystis carinii Serologic Study in Pediatric Acquired Immunodeficiency Syndrome FREE

Linda L. Williford Pifer, PhD; Diane R. Woods; Carol C. Edwards; Rebecca E. Joyner, MT; Frank J. Anderson; Kris Arheart
[+] Author Affiliations

Accepted for publication Sept 1, 1987.

Read before the Society for Pediatric Research, Washington, DC, May 6, 1986.

Reprint requests to Department of Pediatrics, University of Tennessee, Memphis, The Health Science Center, Room F210, Coleman Bldg, 956 Court Ave, Memphis, TN 38163 (Dr Pifer).


Am J Dis Child. 1988;142(1):36-39. doi:10.1001/archpedi.1988.02150010046018.
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References
Comments

• Pneumocystis carinii antigen and IgG antibody profiles were prepared on 17 pediatric patients with acquired immunodeficiency syndrome (AIDS) with pneumonia who were examined by a variety of invasive methods for P carinii organisms. Overall, the accuracy of the antigen assay in invasively examined pediatric patients with AIDS with pneumonia was 94% (sensitivity, 100%; specificity, 90%), as antigen and invasive test results agreed in 16 of 17 patients. No statistically significant differences in IgG titer were observed between controls and patients invasively examined for P carinii, whether the organism was observed in the specimen or not. Since 38% of all serum samples referred were derived from "blood-borne" cases of AIDS, including patients who contracted AIDS as a result of both transfusion and hemophilia A, this suggests that P carinii pneumonia or P carinii pneumonia—like pneumonias may be more common in these individuals.

(AJDC 1988;142:36-39)

REFERENCES

1 +
Centers for Disease Control:  Update: Acquired immunodeficiency syndrome—United States . MMWR 1986;;35:17-19.
2 +
Pifer LLW:  Pneumocystis carinii serology . Clin Immunol Newsletter 1987;;8:7.
3 +
Shann F, Walters S, Pifer LL, et al:  Pneumonia associated with pneumocystis, respiratory syncytial virus, chlamydia, mycoplasma and cytomegalovirus in children in Papua, New Guinea . Br Med J 1986;;292:314-317.
4 +
Jarowenko M, Pifer LL, Kerman R, et al:  Serological methods for the early diagnosis of P carinii infection in renal allograft recipients . Transplantation 1986;;41:436-442.
5 +
Pifer L:  Pneumocystis carinii: A misunderstood opportunist . Eur J Clin Microbiol 1984;;3:169-173.
6 +
Pifer LL, Hughes WT, Stagno S, et al:  Pneumocystis carinii infection: Evidence for high prevalence in normal and immunosuppressed children . Pediatrics 1978;;61:35-41.
7 +
Pifer LL, Hughes WT, Murphy MJ Jr:  Propagation of Pneumocystis carinii in vitro . Pediatr Res 1977;;11:305-316.
8 +
Pifer LL, Pifer DD, Woods DR, et al:  Preliminary studies on the development of a vaccine for Pneumocystis carinii: I. Immunologic and biochemical characterization . Vaccine 1986;;4:257-265.
9 +
Pifer LL: Pneumocystis Antigen and Antibody in Asymptomatic Homosexual Males and in Patients With the Acquired Immunodeficiency Syndrome . Washington, DC, National Institutes of Health AIDS Working Group Report, 1984;.
10 +
Lehmann A: Nonparametrics: Statistical Methods Based on Ranks . New York, McGraw-Hill International Book Co, 1975;.
11 +
Holland M, Douglas A: Nonparametric Statistical Methods . New York, John Wiley & Sons Inc, 1973;.
12 +
Rogers M:  AIDS in children: A review of the clinical, epidemiologic and public health aspects . Pediatr Infect Dis 1986;;4:230-236.
13 +
Blaser MJ, Cohn DL:  Opportunistic infections in patients with AIDS: Clues to the epidemiology of AIDS and the relative virulence of pathogens . Rev Infect Dis 1986;;8:21-30.
14 +
Meuwissen JHE, Tauber I, Leeuwenberg AD:  Parasitologic and serologic observations of infection with pneumocystis in humans . J Infect Dis 1977;;136:43-49.
15 +
Hamlin WB:  Pneumocystis carinii . JAMA 1968;;204:173.
16 +
Weisse K and Wedler E:  Über das Vorkommen der sogenannten 'Pneumocystis carinii.' Klin Wochenschr 1954;;32:270-271.
17 +
Perera DR, Western KA, Johnson HD, et al:  Pneumocystis carinii pneumonia in a hospital for children: Epidemiologic aspects . JAMA 1970;;214:1074-1081.
18 +
Pifer LL:  Pneumocystis carinii: A diagnostic dilemma . Pediatr Infect Dis 1983;;2:177-183.
19 +
Pifer LLW, Niell HB, Langdon SB, et al:  Evidence for depressed humoral immunity to Pneumocystis carinii in homosexual males, commercial plasma donors, and in patients with acquired immunodeficiency syndrome . J Clin Microbiol 1987;;25:993-995.
20 +
Pifer LLW, Wang Y, Chiang R, et al:  Borderline immunodeficiency in male homosexuals: Is lifestyle contributory? South Med J 1987;;80:687-697.
21 +
Pifer LW, Woods DR, Edwards CC, et al:  Pneumocystis carinii antigen and antibody in pediatric acquired immunodeficiency syndrome , abstract 850. Soc Pediatr Res 1986;;20:298.
22 +
Pifer LL:  Pneumocystis carinii , in Easmon CSF, Jeljaszewics J (eds): Medical Microbiology . New York. Harcourt Brace Jovanovich Publishers, 1986;, vol 5, pp 121-171.

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References

1 +
Centers for Disease Control:  Update: Acquired immunodeficiency syndrome—United States . MMWR 1986;;35:17-19.
2 +
Pifer LLW:  Pneumocystis carinii serology . Clin Immunol Newsletter 1987;;8:7.
3 +
Shann F, Walters S, Pifer LL, et al:  Pneumonia associated with pneumocystis, respiratory syncytial virus, chlamydia, mycoplasma and cytomegalovirus in children in Papua, New Guinea . Br Med J 1986;;292:314-317.
4 +
Jarowenko M, Pifer LL, Kerman R, et al:  Serological methods for the early diagnosis of P carinii infection in renal allograft recipients . Transplantation 1986;;41:436-442.
5 +
Pifer L:  Pneumocystis carinii: A misunderstood opportunist . Eur J Clin Microbiol 1984;;3:169-173.
6 +
Pifer LL, Hughes WT, Stagno S, et al:  Pneumocystis carinii infection: Evidence for high prevalence in normal and immunosuppressed children . Pediatrics 1978;;61:35-41.
7 +
Pifer LL, Hughes WT, Murphy MJ Jr:  Propagation of Pneumocystis carinii in vitro . Pediatr Res 1977;;11:305-316.
8 +
Pifer LL, Pifer DD, Woods DR, et al:  Preliminary studies on the development of a vaccine for Pneumocystis carinii: I. Immunologic and biochemical characterization . Vaccine 1986;;4:257-265.
9 +
Pifer LL: Pneumocystis Antigen and Antibody in Asymptomatic Homosexual Males and in Patients With the Acquired Immunodeficiency Syndrome . Washington, DC, National Institutes of Health AIDS Working Group Report, 1984;.
10 +
Lehmann A: Nonparametrics: Statistical Methods Based on Ranks . New York, McGraw-Hill International Book Co, 1975;.
11 +
Holland M, Douglas A: Nonparametric Statistical Methods . New York, John Wiley & Sons Inc, 1973;.
12 +
Rogers M:  AIDS in children: A review of the clinical, epidemiologic and public health aspects . Pediatr Infect Dis 1986;;4:230-236.
13 +
Blaser MJ, Cohn DL:  Opportunistic infections in patients with AIDS: Clues to the epidemiology of AIDS and the relative virulence of pathogens . Rev Infect Dis 1986;;8:21-30.
14 +
Meuwissen JHE, Tauber I, Leeuwenberg AD:  Parasitologic and serologic observations of infection with pneumocystis in humans . J Infect Dis 1977;;136:43-49.
15 +
Hamlin WB:  Pneumocystis carinii . JAMA 1968;;204:173.
16 +
Weisse K and Wedler E:  Über das Vorkommen der sogenannten 'Pneumocystis carinii.' Klin Wochenschr 1954;;32:270-271.
17 +
Perera DR, Western KA, Johnson HD, et al:  Pneumocystis carinii pneumonia in a hospital for children: Epidemiologic aspects . JAMA 1970;;214:1074-1081.
18 +
Pifer LL:  Pneumocystis carinii: A diagnostic dilemma . Pediatr Infect Dis 1983;;2:177-183.
19 +
Pifer LLW, Niell HB, Langdon SB, et al:  Evidence for depressed humoral immunity to Pneumocystis carinii in homosexual males, commercial plasma donors, and in patients with acquired immunodeficiency syndrome . J Clin Microbiol 1987;;25:993-995.
20 +
Pifer LLW, Wang Y, Chiang R, et al:  Borderline immunodeficiency in male homosexuals: Is lifestyle contributory? South Med J 1987;;80:687-697.
21 +
Pifer LW, Woods DR, Edwards CC, et al:  Pneumocystis carinii antigen and antibody in pediatric acquired immunodeficiency syndrome , abstract 850. Soc Pediatr Res 1986;;20:298.
22 +
Pifer LL:  Pneumocystis carinii , in Easmon CSF, Jeljaszewics J (eds): Medical Microbiology . New York. Harcourt Brace Jovanovich Publishers, 1986;, vol 5, pp 121-171.

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