Article |

HIV Embryopathy and Neurocristopathies-Reply

Am J Dis Child. 1988;142(1):10-11. doi:10.1001/archpedi.1988.02150010016004.
Text Size: A A A
Published online

In Reply.—Dr Calvani raises a tantalizing possible explanation for the craniofacial dysmorphism observed in children with evidence of intrauterine HIV infection.1,2 The basis of this theory is that some fundamental interference occurs with the development and migration of cells of the neural crest. This phenomenon would then lead to abnormalities in the structures derived from these cells, namely, the craniofacies, the cardiovascular system, the parathyroid glands, and the thymus. The possible causes of this interference are multiple and include single-gene mutations, chromosomal aberrations, and teratogenic agents. Dr Calvani proposes that in both the fetal AIDS syndrome and the retinoic acid embryopathy, the cause is a teratogen.

This theory has previously been advanced by Lammer et al3 for retinoic acid embryopathy. These authors, noting a recognizable pattern of altered morphogenesis involving the craniofacies, heart, thymus, and brain, postulated that a single mechanism, namely, a deficiency of branchial arch


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview





Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.