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January 1988, Vol 142, No. 1 >
Article | January 1988

HIV Embryopathy and Neurocristopathies FREE

MARIO CALVANI
Am J Dis Child. 1988;142(1):10. doi:10.1001/archpedi.1988.02150010016003.
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Sir.—Marion et al1 have pointed out (1) facial dysmorphism in embryopathy due to human immunodeficiency virus (HIV) and (2) a defect in the immune T-cell system in isotretinoin embryopathy.2 My colleagues and I too have observed the presence of facial dysmorphism in acquired immunodeficiency syndrome (AIDS) embryopathy and have hypothesized a similar defect embryopathy caused by hypervitaminosis A.3 My colleagues and I believe that AIDS and the isotretinoin embryopathies can be included in a more comprehensive syndromic picture, ie, in neurocristopathies that may or may not be linked to chromosomal anomalies (eg, trisomy 13, mosaic monosomy C, fetal alcohol syndrome, Aicardi's syndrome, and de Lange's syndrome),3 with defects in the T-cell system and facial dysmorphism.

There are common characteristics (eg, intrauterine birth defect, microencephalia, prominent forehead, hypertelorism, epicanthal folds, antimongoloid slant of the palpebral fissures, anomalies of the auricle, broad-based nose, saddle nose, micrognathia, and

REFERENCES

1 +
Marion RW, Wiznia AA, Hutcheon RG, et al:  Fetal AIDS syndrome score: Correlation between severity of dysmorphism and age at diagnosis of immunodeficiency . AJDC 1987;;141:429-431.
2 +
Cohen M, Rubinstein A, Li JK, et al:  Thymic hypoplasia associated with isotretinoin embryopathy . AJDC 1987;;141:263-266.
3 +
Calvani M:  Le neurocristopathie ed i difetti del sistema T . Pediatr Oggi 1987;;7:7-17.
4 +
Bockman DE, Kirby ML:  Neural crest interaction in the development of the immune system . J Immunol 1985;;135:766-768.
5 +
Couly C, Lagrue A, Griscelli C:  Le syndrome de Di George: Neurocristopathie rhombencéphalique exemplaire . Rev Stomatol Chir Maxillofac 1983;;84:103-108.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

1 +
Marion RW, Wiznia AA, Hutcheon RG, et al:  Fetal AIDS syndrome score: Correlation between severity of dysmorphism and age at diagnosis of immunodeficiency . AJDC 1987;;141:429-431.
2 +
Cohen M, Rubinstein A, Li JK, et al:  Thymic hypoplasia associated with isotretinoin embryopathy . AJDC 1987;;141:263-266.
3 +
Calvani M:  Le neurocristopathie ed i difetti del sistema T . Pediatr Oggi 1987;;7:7-17.
4 +
Bockman DE, Kirby ML:  Neural crest interaction in the development of the immune system . J Immunol 1985;;135:766-768.
5 +
Couly C, Lagrue A, Griscelli C:  Le syndrome de Di George: Neurocristopathie rhombencéphalique exemplaire . Rev Stomatol Chir Maxillofac 1983;;84:103-108.

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