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Hemostasis Defects and Periventricular-Intraventricular Hemorrhage-Reply

Margot van de Bor, MD, PHD; Frank van Bel, MD; Jan H. Ruys, MD, PHD; Ernest Briët, MD, PHD
Am J Dis Child. 1987;141(10):1041. doi:10.1001/archpedi.1987.04460100018011.
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In Reply.—In our first report we stated that infants who developed PIVH during the study period required more plasma transfusions during the first week of life but that plasma transfusion itself appeared to be no antecedent of PIVH.1 In our second report2 we mentioned explicitly that the clotting factor levels on day 1 in infants, who died during the study period were not different from those of the other infants enrolled in the study.

To allow comparison among all infants we decided only to study the infants who survived the whole study period. Beverley and coworkers3 found no statistical differences among the infants with PIVH and without PIVH in any of the clotting factors at birth, although after subdivision of infants with PIVH according to the severity of the hemorrhage, the infants with more severe hemorrhages had evidence of coagulopathy at birth. Beverley et al also

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