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September 1987, Vol 141, No. 9 >
Article | September 1987

Anaphylactic Shock due to Cytarabine in a Leukemic Child FREE

Frank E. Berkowitz, MBBCh, FCP; Sabrina Wehde, MBBCh; Edwin T. Ngwenya, MBBCh; Michael Greeff, MBBCh, FCP; Ahmed A. Wadee, PhD; Arthur R. Rabson, MBBCh, MRCPath
[+] Author Affiliations

Accepted for publication March 18, 1987.

Reprint requests to Baragwanath Hospital, PO Bertsham, Johannesburg 2013, South Africa (Dr Berkowitz).


Am J Dis Child. 1987;141(9):1000-1001. doi:10.1001/archpedi.1987.04460090077031.
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• In a young child with acute promyelocytic leukemia, treatment with a variety of chemotherapeutic agents produced an acute anaphylactic reaction. When cytarabine was removed from the chemotherapeutic regimen, no further anaphylaxis occurred. Employing an enzyme-linked Immunosorbent assay with cytarabine coated onto the wells in bovine serum albumin, specific IgE antibodies to this drug could be demonstrated. Similar antibodies could not be demonstrated in the serum of normal controls or of two other patients receiving cytarabine. We therefore document anaphylactic shock mediated by specific IgE antibodies to cytarabine.

(AJDC 1987;141:1000-1001)

REFERENCES

1 +
Grier HE, Weinstein HJ:  Acute nonlymphocytic leukemia . Pediatr Clin North Am 1985;;32: 653-668.
2 +
Bleyer WA:  Cancer chemotherapy in infants and children . Pediatr Clin North Am 1985;;32: 557-574.
3 +
Rassiga AL, Schwartz HJ, Forman WB, et al:  Cytarabine-induced anaphylaxis: Demonstration of antibody and successful desensitization . Arch Intern Med 1980;;140:425-427.
Link to Article
4 +
Markman M, Howell SB, King M, et al:  Anaphylactic reaction to cytarabine: In vitro evidence that the response is immunoglobulin E mediated . Med Pediatr Oncol 1984;;12:201-203.
Link to Article
5 +
Jones GR, Ettinger LJ:  Continuous infusion of high-dose cytosine arabinoside for treatment of childhood acute leukemia and non-Hodgkin's lymphoma in relapse . Semin Oncol 1985;;12( (suppl 3) ):150-154.
6 +
Weiss RB:  Hypersensitivity reactions to cancer chemotherapy . Semin Oncol 1982;;9:5-13.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

1 +
Grier HE, Weinstein HJ:  Acute nonlymphocytic leukemia . Pediatr Clin North Am 1985;;32: 653-668.
2 +
Bleyer WA:  Cancer chemotherapy in infants and children . Pediatr Clin North Am 1985;;32: 557-574.
3 +
Rassiga AL, Schwartz HJ, Forman WB, et al:  Cytarabine-induced anaphylaxis: Demonstration of antibody and successful desensitization . Arch Intern Med 1980;;140:425-427.
Link to Article
4 +
Markman M, Howell SB, King M, et al:  Anaphylactic reaction to cytarabine: In vitro evidence that the response is immunoglobulin E mediated . Med Pediatr Oncol 1984;;12:201-203.
Link to Article
5 +
Jones GR, Ettinger LJ:  Continuous infusion of high-dose cytosine arabinoside for treatment of childhood acute leukemia and non-Hodgkin's lymphoma in relapse . Semin Oncol 1985;;12( (suppl 3) ):150-154.
6 +
Weiss RB:  Hypersensitivity reactions to cancer chemotherapy . Semin Oncol 1982;;9:5-13.

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