Cerebral Infarction in Persistent Pulmonary Hypertension of the Newborn FREE

Kenneth W. Klesh, MD; Timothy F. Murphy, PhD; Mark S. Scher, MD; Donald E. Buchanan, MD; Elizabeth P. Maxwell, MS; Robert D. Guthrie, MD

[+] Author Affiliations

Accepted for publication Nov 18, 1986.

Reprint requests to Department of Pediatrics, Magee-Womens Hospital, Forbes Avenue and Halket Street, Pittsburgh, PA 15213 (Dr Klesh).

Am J Dis Child. 1987;141(8):852-857. doi:10.1001/archpedi.1987.04460080038023.

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ABSTRACT

ABSTRACT | REFERENCES

• Persistent pulmonary hypertension of the newborn and its attendant hypoxemia may place the Infant at high risk for hypoxic-ischemic injury. In 19 infants with persistent pulmonary hypertension of the newborn, 16 of whom suffered Intrapartum asphyxia, we evaluated a series of electroencephalograms (EEGs) for evidence of major focal cerebral injury, ie, persistent voltage attenuation and/or focal electrical-seizure activity. Of the 15 Infants (78.9%) with such EEG findings, nine infants (47% of the total population) had cerebral infarction documented by cranial sonograms, computed tomographic scans, or autopsy findings. In eight (89%) of the nine infants with infarction, electrical seizures were noted during periods of muscle paralysis. We recommend (1) the use of electroencephalography in this population, particularly during periods of muscle paralysis, to detect underlying cerebrovascular lesions and (2) the use of cranial computed tomography if persistent, focal EEG abnormalities are noted.

(AJDC 1987;141:852-857)

REFERENCES

ABSTRACT | REFERENCES

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