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Sweet's Syndrome and Chronic Recurrent Multifocal Osteomyelitis-Reply

Thomas C. Edwards, MD; F. Bruder Stapleton, MD
Am J Dis Child. 1987;141(7):721. doi:10.1001/archpedi.1987.04460070023010.
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In Reply.—We appreciate Dr Arndt's comments regarding our article describing a child with Sweet's syndrome. The recognition of Sweet's syndrome is increasing, both in the United States and abroad. Since our article was submitted, there have been two articles published regarding Sweet's syndrome1,2 as well as another article concerning CRMO.3 As our article discusses, CRMO and pustulosis palmoplantaris appear to be distinct entities from Sweet's syndrome. However, there are some similarities between these three idiopathic inflammatory syndromes; it is possible that they represent different manifestations of a similar underlying pathologic process.

The article by Weiner et al describes a 7-year-old with CRMO and pustulosis palmoplantaris with skin lesions distinctive from those of Sweet's syndrome. The long-bone lesions described are, however, similar to the lesions in our patient with Sweet's syndrome. It is possible that bony lesions are a component of Sweet's syndrome that is not often recognized.

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