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Picture of the Month

Stephen E. Pascucci, MD; Curtis E. Margo, MD; Murray Feingold, MD
Am J Dis Child. 1987;141(6):643-644. doi:10.1001/archpedi.1987.04460060061034.
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The statements listed below are best associated with which of the above figures:

  • If other congenital anomalies are present, a chromosomal analysis is indicated.

  • The diagnosis of retinoblastoma should be considered.

  • Infants with this condition may have excessive tearing and photophobia, and they require immediate surgery.

Denouement and Discussion  Fig 1.—Abnormal appearance of white pupil due to mass behind crystalline lens. Normal light reflex in pupil is lost because retinoblastoma has caused retinal detachment.Fig 2.—Enlarged hazy cornea in infant with congenital glaucoma.Fig 3.—Iris coloboma.(a)

  • An iris coloboma (Fig 3) in the presence of other congenital anomalies may also be associated with various chromosomal abnormalities, such as deletion of the short (p) arm of chromosome 4. It usually results from failure of fusion of the embryonic fissure of the optic cup. A child with an iris coloboma should have a thorough ocular examination because of


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