We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Possible Similarities Between the Fragile X and Asperger's Syndromes-Reply

Randi J. Hagerman, MD
Am J Dis Child. 1987;141(6):601-602. doi:10.1001/archpedi.1987.04460060019009.
Text Size: A A A
Published online


In Reply.—Drs Bartolucci and Szatmari present an interesting speculation that I have considered many times in the past. Although approximately 16% of male children with fra(X) chromosome will fulfill Diagnostic and Statistical Manual, ed 3, criteria for infantile autism, the majority of boys with fra(X) syndrome demonstrate only some autistic features, such as hand flapping, hand biting, and poor eye contact without a pervasive lack of relatedness.1 These problems, combined with perseverations in language and behavior, such as fascination with spinning objects, makes one consider the terms autisticlike or a high-functioning autistic child, and yet many children with fra(X) syndrome can relate quite well to their family and peers. The juxtaposition of an ability to relate with some autistic features is perhaps the source of controversy concerning the incidence of autism in fra(X) syndrome and the incidence of fra(X) chromosome in autism.

Asperger's syndrome can be simplistically viewed


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.