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Dysmorphism Leading to a Diagnosis of Acquired Immunodeficiency Syndrome-Reply

Robert W. Marion, MD; Andrew A. Wiznia, MD; R. Gordon Hutcheon, MD; Arye Rubinstein, MD
Am J Dis Child. 1987;141(5):474. doi:10.1001/archpedi.1987.04460050016004.
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In Reply.—The practical importance of the recognition of an HTLV-III embryopathy is that presence of the features in an infant or child allows diagnosis of infection prior to the onset of clinical symptoms consistent with AIDS. As such, it is gratifying to read of Dr Perro's experience. The patient described, a 2-year-old female, did not have all of the features we reported. This has been our experience as well: children who are the most stigmatized (the ones who have all of the features of the HTLV-III embryopathy) manifest symptoms of AIDS early, usually within the first six months of life; children who manifest partial expression of the HTLV-III embryopathy tend to be diagnosed later, as was the case with Dr Perro's patient.


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