We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Isolated IgG4 Subclass Deficiency and Malignant Lymphoma in a Child With Acquired Immunodeficiency Syndrome

Nathan S. Honda, MD; Nora C. J. Sun, MD; Douglas C. Heiner, MD, PhD
Am J Dis Child. 1987;141(4):398-399. doi:10.1001/archpedi.1987.04460040056008.
Text Size: A A A
Published online


Sir.—A 21-month-old female infant with acquired immunodeficiency syndrome (AIDS) was found to have an isolated IgG4 subclass deficiency. She died, and it was found at postmortem examination that she had a disseminated undifferentiated B-cell lymphoma. Specific immunoglobulin subclass deficiencies have previously been reported in patients with persistent or recurrent respiratory tract infections and recently in infants with AIDS. However, to our knowledge, an isolated deficiency of IgG4 has not previously been reported to be associated either with AIDS or with the development of B-cell lymphoma.

Patient Report.—The patient was a 21-month-old Hispanic female infant admitted to Harbor-UCLA Medical Center, Torrance, Calif, because of unremitting diarrhea of two weeks' duration. She was the product of a term gestation with normal birth weight. There was chronic anemia, for which blood transfusions were given at 1 and 2 months of age. There were subsequently multiple episodes of diarrhea that often required


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.