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Kawasaki Disease and Hepatitis B: Lack of Association

Harry Kaplovitz, MD; Deborah Friedman, MD; Keith Krasinski, MD
Am J Dis Child. 1987;141(2):126. doi:10.1001/archpedi.1987.04460020016008.
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Sir.—Kawasaki disease (KD) occurs frequently in the Japanese population1 and is often associated with abnormalities of liver function.2,3 Hepatitis B virus infection (HBV) is also common in Asian people4 and has recently been associated with diseases mediated by immune complexes.5-7 Immune complex vasculitis due to HBV sometimes takes the form of glomerulonephritis8 or essential-mixed cryoglobulinemia9 and resembles certain aspects of KD. The present study investigated the possibility of an association between HBV and KD.

Patients and Methods.—Thirty-eight patients with previously diagnosed KD who had undergone echocardiography were contacted. Fifteen patients were enrolled in the study after parental informed consent was obtained. Ages ranged from 1 to 12 years (mean age, 3.5 years), and eight of 15 patients were boys. Ethnicity was typical of the local population and showed 13 whites or Hispanics, two blacks, and no Asians. The interval from onset

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