We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Right Ventricular Cardiac Dysfunction in β-Thalassemia Major

Ariel Koren (Kurlat), MD; Itzhak Garty, MD; Dante Antonelli, MD; Eliahu Katzuni, MD
Am J Dis Child. 1987;141(1):93-96. doi:10.1001/archpedi.1987.04460010093035.
Text Size: A A A
Published online


• In patients with iron overload associated with severe, transfusion-dependent β-thalassemia, congestive heart failure develops during the second decade of life. Biventricular heart function Was studied by multigated radionuclide angiography In 22 patients with β-thalassemia major. Six patients were symptomatic. Congestive heart failure developed in five patients at the time of blood transfusions, and one other patient had been treated for multiple ventricular extrasystole. The mean (±SD) left ventricular ejection fraction was normal (63.0%± 7.6%). Only one patient had a left ventricular ejection fraction under the normal level (<50%). The mean (± SD) right ventricular fraction (RVEF) was 33.3%±9.4%. In only three patients Was the RVEF normal (≥40%); an RVEF under 30% was registered in six patients. We suggest that the early right ventricular dysfunction in patients with β-thalassemia may be due to pulmonary hypertension secondary to iron overload and iron deposits in the ventricles.

(AJDC 1987;141:93-96)


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.