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Thrombocytopenia in an Infant With AIDS

Mark E. Weinblatt, MD; Philip G. Scimeca, MD; Angelica G. James-Herry, MD; Savita Pahwa, MD
Am J Dis Child. 1987;141(1):15. doi:10.1001/archpedi.1987.04460010015012.
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Sir.—The clinical spectrum of the acquired immunodeficiency syndrome (AIDS) in children has continued to expand. Reported abnormalities include failure to thrive, chronic interstitial pneumonitis, hepatosplenomegaly, diffuse adenopathy, protracted diarrhea, recurrent otitis media, eczematoid rashes, and thrombocytopenia.1 Low platelet count has been shown to be due to increased destruction, although the pathogenesis remains unclear.2,3 We report a case of thrombocytopenia secondary to selective bone marrow failure in a child with AIDS.

Patient Report.—The patient was the 1090-g male product of a 28-week gestation. He was born to a 31-year-old known intravenous drug abuser. The neonatal course was complicated by respiratory distress syndrome and moderate bronchopulmonary dysplasia, poor weight gain, hyperbilirubinemia, hypocalcemia, hypoglycemia, a moderate germinal matrix hemorrhage, and transient severe ischemia to the right lower extremity. Immunologic and serologic studies performed on the mother shortly after delivery revealed a T4/T8 ratio of 0.6 and

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