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Long-term Bromocriptine Treatment for Prolactin-Secreting Macroadenoma

Am J Dis Child. 1986;140(12):1216-1217. doi:10.1001/archpedi.1986.02140260018016.
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Sir.—Prolactin-secreting adenomas occur rarely in children. Very few have been reported in children of peripubertal age.1-3 We describe one of the youngest female patients to have a prolactin-secreting macroadenoma that was treated successfully with longterm administration of bromocriptine.

Patient Report.—The patient presented at 13 years of age with secondary amenorrhea, galactorrhea, an 18-kg weight gain, intermittent, right-sided, frontoparietal dull headaches, and diplopia. Menarche occurred at 11.6 years of age; normal menses continued until 12.3 years of age. The patient was 155 cm tall (45th percentile), weighed 81 kg (95th percentile), and was at Tanner stage V of pubertal development. Galactorrhea was easily demonstrated. Results of neurologic and visual field examinations were normal.

The serum prolactin level was elevated to 316 ng/mL (316 μg/L) (normal, <25 ng/mL [<25 μg/L). A complete blood cell count, blood chemistry profile, and results of thyroid and adrenal studies were normal. The thyroid-stimulating


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