Sir.—Nephrogenic diabetes insipidus is a congenital disorder characterized by insensitivity of the renal tubule to antidiuretic hormone. This congenital hereditary disorder has been associated with a number of central nervous system disorders, but an association with hydrocephalus has not been reported.u We describe a 15-week-old female infant with hydrocephalus and severe nephrogenic diabetes insipidus.
Patient Report.—A 15-week-old female infant was admitted to the pediatrie intensive care unit, Cook County Hospital, Chicago, for severe hypernatremic dehydration. She was a 3799-g product of a 39-week gestation, born to a gravida 2, para 1 19year-old woman by cesarean section for cephalopelvic disproportion; her Apgar scores were 8 and 8 at one and five minutes, respectively. Results of an examination were normal except for an enlarged head. The head circumference was greater than the 90th percentile; the length and weight were at the 50th to 75th percentiles. Ultrasound examination of the