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Nephrogenic Diabetes Insipidus in a Female Infant With Hydrocephalus

Am J Dis Child. 1986;140(11):1095-1096. doi:10.1001/archpedi.1986.02140250021013.
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Sir.—Nephrogenic diabetes insipidus is a congenital disorder characterized by insensitivity of the renal tubule to antidiuretic hormone. This congenital hereditary disorder has been associated with a number of central nervous system disorders, but an association with hydrocephalus has not been reported.u We describe a 15-week-old female infant with hydrocephalus and severe nephrogenic diabetes insipidus.

Patient Report.—A 15-week-old female infant was admitted to the pediatrie intensive care unit, Cook County Hospital, Chicago, for severe hypernatremic dehydration. She was a 3799-g product of a 39-week gestation, born to a gravida 2, para 1 19year-old woman by cesarean section for cephalopelvic disproportion; her Apgar scores were 8 and 8 at one and five minutes, respectively. Results of an examination were normal except for an enlarged head. The head circumference was greater than the 90th percentile; the length and weight were at the 50th to 75th percentiles. Ultrasound examination of the


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