0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Lymphocyte Subpopulations and Corticosteroid Treatment in Patients With Pertussis

DONATO TORRE, MD; F. MAGGIOLO, MD; C. SAMPIETRO, MD; G. INGROSSO, MD; M. Issi, MD; D. Rossi, MD
Am J Dis Child. 1986;140(11):1094. doi:10.1001/archpedi.1986.02140250020011.
Text Size: A A A
Published online

Sir.—Immunity in pertussis has not yet been clarified; local immunity probably plays an important role, as Bordetella pertussis causes a noninvasive infection that is restricted to the ciliated respiratory epithelial cells. On the other hand, a toxin produced by B pertussis, lymphocytosispromoting factor, is responsible for systemic manifestations. Hewlett et al1 showed that B pertussis causes an impairment of cell-mediated immunity in children that is reversible with recovery. The use of corticosteroids in pertussis remains controversial; Zoumboulakis et al2 and Chandra et al3 demonstrated a beneficial effect of corticosteroids in reducing the severity and the number of attacks of whooping; however, corticosteroids can impair cellular immunity and could lead to severe complications.

Patients and Methods.—To analyze the role of B pertussis and corticosteroid treatment, we examined T-lymphocyte subpopulations of 11 patients with pertussis. Patients were admitted to our division with the diagnosis of pertussis based

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();