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Peptic Ulcer Disease in Cystic Fibrosis: An Unusual Occurrence in Black Adolescents FREE

BERYL J. ROSENSTEIN, MD; JAY A. PERMAN, MD; SANDRA S. KRAMER, MD
Am J Dis Child. 1986;140(10):966-969. doi:10.1001/archpedi.1986.02140240012003.
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Sir.—Cystic fibrosis (CF) is the most common genetic disease affecting children in the United States, with an incidence of one per 2000 whites and one per 17 000 blacks.1 In 1982 only 2.6% of the 13 487 patients added to the registry of the Cystic Fibrosis Foundation were black.2 Although a variety of gastrointestinal tract complications has been reported in patients with CF,3 an Clinical Features of Three Black Patients With Cystic Fibrosis and Peptic Ulcer Disease* Patient/Sex CF Presentation Subsequent Clinical Findings Ulcer Presentation Status at Last Evaluation 1/M 2/F 3/M At age 8 y; mild asthma; nasal polyps; sweat chloride:112, 88 mEq/L (mmol/L) (normal <60) At age 23 y; hemoptysis; sweat chloride: 64, 70 mEq/ L (mmol/L) At age 18 y; chronic cough; hemoptysis; sweat chloride: 149,84, 112 mEq/L (mmol/L) Opacification of paranasal sinuses; digital clubbing; decreased pulmonary function Steatorrhea; opacification of paranasal

REFERENCES

Wood RE, Boat TF, Doershuk CF:  Cystic fibrosis . Am Rev Respir Dis 1976;;113:833-878.
Patient Registry . Rockville, Md, Cystic Fibrosis Foundation, 1982;.
Shwachman H:  Gastrointestinal manifestations of cystic fibrosis . Pediatr Clin North Am 1975;;22:787-805.
Boyd EJS, Wormsley KG:  Etiology and pathogenesis of peptic ulcer , in Berk JE (ed): Bockus Gastroenterology . Philadelphia, WB Saunders Co, 1985;, pp 1013-1059.
Oppenheimer EH, Esterly JR:  Pathology of cystic fibrosis: Review of the literature and comparison with 146 autopsied cases . Perspect Pediatr Pathol 1975;;2:241-278.
Markel IJ:  Fibrocystic disease of the pancreas with an unusual lesion . Indiana Med 1944;; 37:674.
Aterman K:  Duodenal ulceration and fibrocystic pancreas disease . AJDC 1961;;101:210-215.
Grossman H, Berdon WE, Baker DH:  Gastrointestinal findings in cystic fibrosis . AJR 1966;;97:227-238.
Link to Article
Seagram CA, Stephens CA, Cumming WA:  Peptic ulceration at the Hospital for Sick Children, Toronto, during the 20-year period 1949-1969 . J Pediatr Surg 1973;;8:407-413.
Link to Article
Phelan MS, Fine DR, Zentler-Munro PH, et al:  Radiographic abnormalities of the duodenum in cystic fibrosis . Clin Radiol 1983;;34: 573-577.
Link to Article
Park RW, Grand RJ:  Gastrointestinal manifestations of cystic fibrosis: A review . Gastroenterology 1981;;81:1143-1161.
Di Sant'Agnese PA, Davis PB:  Cystic fibrosis in adults . Am J Med 1979;;66:121-132.
Link to Article
Stern RC, Doershuk CF, Boat TF, et al:  Course of cystic fibrosis in black patients . J Pediatr 1976;;89:412-417.
Link to Article
Sultz HA, Schlesinger ER, Feldman JG, et al:  The epidemiology of peptic ulcer in childhood . Am J Public Health 1970;;60:492-498.
Link to Article
Miranti JP:  A review of experience with peptic ulcer in adolescents and young adults in a university health service . J Am Coll Health 1970;;18:381.
Damon A, Polednak AP:  Constitution, genetics, and body form in peptic ulcer: A review . J Chronic Dis 1967;;20:787-802.
Link to Article
Kurata JH, Haile BM:  Racial differences in peptic ulcer disease: Fact or myth? Gastroenterology 1982;;83:166-172.
Zasly L, Baum GL, Rumball JM:  The incidence of peptic ulceration in chronic obstructive pulmonary emphysema . Chest 1960;;37:400-405.
Link to Article
Dreiling DA, Naqvi MA:  Peptic ulcer diathesis in patients with chronic pancreatitis . Am J Gastroenterol 1969;;51:503-510.
Dutta SK, Russell RM, Iber FL:  Impaired acid neutralization in the duodenum in pancreatic insufficiency . Dig Dis Sci 1979;;24:775-780.
Link to Article
Saunders JHB, Cargill JM, Wormsley KG:  Gastric secretion of acid in patients with pancreatic disease . Digestion 1978;;17:365-369.
Link to Article
Hadorn B, Zoppi G, Shmerling DH, et al:  Quantitative assessment of exocrine pancreatic function in infants and children . J Pediatr 1968;; 73:39-50.
Link to Article
Cox K, Isenberg JN, Ament ME:  Gastric acid hypersecretion in cystic fibrosis . J Pediatr Gastroenterol Nutr 1982;;1:559-565.
Link to Article
Zentler-Munro PL, Northfield MD, Batten MD:  The role of bile acid precipitation in fat maldigestion , in Sturgess JM (ed): Perspectives in Cystic Fibrosis . Toronto, Imperial Press, 1980;, p 39a.

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References

Wood RE, Boat TF, Doershuk CF:  Cystic fibrosis . Am Rev Respir Dis 1976;;113:833-878.
Patient Registry . Rockville, Md, Cystic Fibrosis Foundation, 1982;.
Shwachman H:  Gastrointestinal manifestations of cystic fibrosis . Pediatr Clin North Am 1975;;22:787-805.
Boyd EJS, Wormsley KG:  Etiology and pathogenesis of peptic ulcer , in Berk JE (ed): Bockus Gastroenterology . Philadelphia, WB Saunders Co, 1985;, pp 1013-1059.
Oppenheimer EH, Esterly JR:  Pathology of cystic fibrosis: Review of the literature and comparison with 146 autopsied cases . Perspect Pediatr Pathol 1975;;2:241-278.
Markel IJ:  Fibrocystic disease of the pancreas with an unusual lesion . Indiana Med 1944;; 37:674.
Aterman K:  Duodenal ulceration and fibrocystic pancreas disease . AJDC 1961;;101:210-215.
Grossman H, Berdon WE, Baker DH:  Gastrointestinal findings in cystic fibrosis . AJR 1966;;97:227-238.
Link to Article
Seagram CA, Stephens CA, Cumming WA:  Peptic ulceration at the Hospital for Sick Children, Toronto, during the 20-year period 1949-1969 . J Pediatr Surg 1973;;8:407-413.
Link to Article
Phelan MS, Fine DR, Zentler-Munro PH, et al:  Radiographic abnormalities of the duodenum in cystic fibrosis . Clin Radiol 1983;;34: 573-577.
Link to Article
Park RW, Grand RJ:  Gastrointestinal manifestations of cystic fibrosis: A review . Gastroenterology 1981;;81:1143-1161.
Di Sant'Agnese PA, Davis PB:  Cystic fibrosis in adults . Am J Med 1979;;66:121-132.
Link to Article
Stern RC, Doershuk CF, Boat TF, et al:  Course of cystic fibrosis in black patients . J Pediatr 1976;;89:412-417.
Link to Article
Sultz HA, Schlesinger ER, Feldman JG, et al:  The epidemiology of peptic ulcer in childhood . Am J Public Health 1970;;60:492-498.
Link to Article
Miranti JP:  A review of experience with peptic ulcer in adolescents and young adults in a university health service . J Am Coll Health 1970;;18:381.
Damon A, Polednak AP:  Constitution, genetics, and body form in peptic ulcer: A review . J Chronic Dis 1967;;20:787-802.
Link to Article
Kurata JH, Haile BM:  Racial differences in peptic ulcer disease: Fact or myth? Gastroenterology 1982;;83:166-172.
Zasly L, Baum GL, Rumball JM:  The incidence of peptic ulceration in chronic obstructive pulmonary emphysema . Chest 1960;;37:400-405.
Link to Article
Dreiling DA, Naqvi MA:  Peptic ulcer diathesis in patients with chronic pancreatitis . Am J Gastroenterol 1969;;51:503-510.
Dutta SK, Russell RM, Iber FL:  Impaired acid neutralization in the duodenum in pancreatic insufficiency . Dig Dis Sci 1979;;24:775-780.
Link to Article
Saunders JHB, Cargill JM, Wormsley KG:  Gastric secretion of acid in patients with pancreatic disease . Digestion 1978;;17:365-369.
Link to Article
Hadorn B, Zoppi G, Shmerling DH, et al:  Quantitative assessment of exocrine pancreatic function in infants and children . J Pediatr 1968;; 73:39-50.
Link to Article
Cox K, Isenberg JN, Ament ME:  Gastric acid hypersecretion in cystic fibrosis . J Pediatr Gastroenterol Nutr 1982;;1:559-565.
Link to Article
Zentler-Munro PL, Northfield MD, Batten MD:  The role of bile acid precipitation in fat maldigestion , in Sturgess JM (ed): Perspectives in Cystic Fibrosis . Toronto, Imperial Press, 1980;, p 39a.

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