1% Permethrin Cream Rinse vs 1% Lindane Shampoo in Treating Pediculosis Capitis FREE

Kathie Brandenburg, RN, MS; Amos S. Deinard, MD, MPH; Joan DiNapoli, RN, PhD; Steven J. Englender, MD, MPH; Joseph Orthoefer, DVM, MPH; Doris Wagner, RN, MS

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Accepted for publication June 3, 1986.

Reprint requests to Box 85, University of Minnesota Hospital, Minneapolis, MN 55455 (Dr Deinard).

Am J Dis Child. 1986;140(9):894-896. doi:10.1001/archpedi.1986.02140230064034.

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ABSTRACT

ABSTRACT | REFERENCES

• The therapeutic efficacy and tolerance of a single application of 1% permethrin cream rinse, applied for ten minutes, and a single application of 1% lindane shampoo applied, as recommended by the manufacturer, for four minutes, against the head louse Pediculus humanus var capitis were compared in a single-blinded, randomized, controlled clinical trial. Of 573 patients enrolled at eight centers, 559 were assessable for tolerance and 508 for efficacy. Of the 257 patients treated with 1% permethrin cream rinse, 99% were lice free at 14 days; of the 251 patients treated with 1% lindane shampoo, 85% were lice free at 14 days. The difference is statistically significant. For both treatments, adverse experiences were infrequent, mild, and usually difficult to distinguish from the symptoms of head lice infestation. A single ten-minute application of 1% permethrin cream rinse was well tolerated, highly effective, and therapeutically superior to a single four-minute application of 1% lindane shampoo.

(AJDC 1986;140:894-896)

REFERENCES

ABSTRACT | REFERENCES

Slonka GF, Fleissner ML, Berlin J, et al: An epidemic of pediculosis capitis . J Parasitol 1977;; 63:377-383.

Billstein S, Laone P: Demographic study of head lice infestations in Sacramento County school children . Int J Dermatol 1979;;18:301-304.

Lange K, Nielson AO, Jensen O, et al: Pyriderm shampoo in the treatment of pediculosis capitis . Acta Dermatol 1981;;61:91-92.

Robinson DH, Shepherd DA: Control of head lice in school-children . Curr Ther Res 1980;; 27:1-6.

Tentative Findings of the Advisory Review Panel on OTC Pediculicide Drug Products , Food and Drug Administration bulletin 85-5A-38, 1980;.

Mathias RG, Huggins DR, Leroux SJ, et al: Comparative trial of treatment with Prioderm lotion and Kwellada shampoo in children with head lice . Can Med Assoc J 1984;;130:407-409.

Taplin D: Response to letter to the editor . J Am Acad Dermatol 1983;;8:120-121.

Davies JE, Dedhia HV, Morgade C, et al: Lindane poisonings . Arch Dermatol 1983;;119: 142-144.

Lee B, Groth P, Turner W: Suspected reactions to gamma benzene hexachloride . JAMA 1976;;236:2846.

Loge JP: Aplastic anemia following exposure to benzene hexachloride (lindane) . JAMA 1965;;193:104-108.

Hans RJ: Aplastic anemia associated with γ-benzene hexachloride . JAMA 1976;;236:1009-1010.

Solomon LM, West DP, Fiszloff JF, et al: Lindane in guinea pig brain after topical application . J Invest Dermatol 1977;;68:310-312.

Desi I: Neurotoxicological effect of small quantities of lindane . Int Arch Arbeitsmed 1974;;33:153-162.

Vijverberg HP, van den Bersken T: Action of pyrethroid insecticides on the vertebrate nervous system . Neuropathol Appl Neurobiol 1982;; 8:421-440.

Kaufman DD, Haynes S, Jordan G, et al: Permethrin degradation in soil and microbial cultures , in Eliot M (ed): Synthetic Pyrethroids , American Chemical Society Symposium Series No. 42. Washington, DC, American Chemical Society, 1977;, pp 147-161.

Flannigan SA, Tucker SB, Key MM, et al: Synthetic pyrethroid insecticides: A dermatologic evaluation . Br J Ind Med 1985;;42:363-372.

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