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How Useful Is the Barium Enema in the Diagnosis of Infantile Hirschsprung's Disease? FREE

Thomas L. Taxman, MD; Barry S. Yulish, MD; Fred C. Rothstein, MD
[+] Author Affiliations

Accepted for publication May 21, 1986.

Reprint requests to Department of Pediatrics, Cleveland Metropolitan General Hospital, 3395 Scranton, Cleveland, OH 44109 (Dr Taxman).


Am J Dis Child. 1986;140(9):881-884. doi:10.1001/archpedi.1986.02140230051028.
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• We studied the usefulness of the barium enema to rule out Hirschsprung's disease (congenital megacolon) in the evaluation of infants with constipation. Results from barium enemas in 58 constipated infants and children who underwent rectal suction biopsies to rule out aganglionosis were evaluated in retrospect for the presence of a transition zone, delayed evacuation of barium, and colonic anatomic abnormalities. As expected, the presence of a transition zone was most accurate in predicting Hirschsprung's disease. Eighty percent of infants with aganglionosis had a roentgenographic transition zone, while 20% did not. Twenty-nine percent of infants with a suspected roentgenographic transition zone did not have aganglionosis. Delayed evacuation of barium was a poor predictor of aganglionosis. The presence of delayed evacuation of barium did not improve the accuracy of the transition zone to predict Hirschsprung's disease. Barium enemas did not reveal any additional colonic anatomic defects other than a transition zone to account for constipation in our study group. These results demonstrated that the barium enema is not a specific enough screening procedure to rule out Hirschsprung's disease in the unobstructed infant. Rectal suction biopsy is diagnostic and should be performed as the procedure of choice in those infants suspected of having Hirschsprung's disease.

(AJDC 1986;140:881-884)

REFERENCES

Swenson O, Fisher JH, MacMahon AE:  Rectal biopsy as an aid in the diagnosis of Hirschsprung's disease . N Engl J Med 1955;;253:632-635.
Andrassy RJ, Isaacs H, Weitzman JJ:  Rectal suction biopsy for the diagnosis of Hirschsprung's disease . Ann Surg 1981;;193:419-424.
Yunis EJ, Dibbins AW, Sherman FE:  Rectal suction biopsy in the diagnosis of Hirschsprung's disease in infants . Arch Pathol Lab Med 1976;;100: 329-333.
Swischuk LE:  Meconium plug syndrome: A cause of neonatal intestinal obstruction . AJR 1968;;103:339-346.
Pochaczevsky R, Leonidas JC:  The rectosigmoid index: A measurement for the early diagnosis of Hirschsprung's disease . AJR 1975;;123: 770-777.
Siegel MJ, Shackelford GD, McAlister WH:  The rectosigmoid index . Radiology 1981;;139:497-499.
Swenson O, Newhauser EBD, Picket LK:  New concepts of etiology, diagnosis and treatment of congenital megacolon (Hirschsprung's disease) . Pediatrics 1949;;4:201-209.
Ehrenpreis T:  Megacolon in the newborn: Clinical and roentgenological study with special regard to pathogenesis . Acta Paediatr 1945;;32: 358-370.
Berman CZ:  Roentgenographic manifestations of congenital megacolon (Hirschsprung's disease) in early infancy . Pediatrics 1956;;18:227-238.
Kleinhaus S, Boley SJ, Sheran M, et al:  Hirschsprung's disease: A survey of the members of the surgical section of the American Academy of Pediatrics . J Pediatr Surg 1979;;14:588-597.
Evans WA, Willis R:  Hirschsprung's disease: The roentgen diagnosis in infants . AJR 1957;;78:1024-1048.
McDonald RG, Evans WA:  Hirschsprung's disease: Roentgen diagnosis in infants . AJDC 1954;;87:575-585.
Rosenfeld NS, Ablow RC, Markowitz RI, et al:  Hirschsprung's disease: Accuracy of the barium enema examination . Radiology 1984;;150: 393-400.
Berdon WE, Baker DH:  The roentgenographic diagnosis of Hirschsprung's disease in infancy . AJR 1965;;93:432-446.
Schey WC, White H:  Hirschsprung's disease: Problems in the roentgen interpretation . AJR 1971;;112:105-115.
Swenson O, Sherman JO, Fisher JH:  Diagnosis of congenital megacolon: An analysis of 501 patients . J Pediatr Surg 1973;;8:587-593.
Kottmeier P, Clatworthy W:  Aganglionosis and functional megacolon in children: A diagnostic dilemma . Pediatrics 1965;;36:572-582.

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References

Swenson O, Fisher JH, MacMahon AE:  Rectal biopsy as an aid in the diagnosis of Hirschsprung's disease . N Engl J Med 1955;;253:632-635.
Andrassy RJ, Isaacs H, Weitzman JJ:  Rectal suction biopsy for the diagnosis of Hirschsprung's disease . Ann Surg 1981;;193:419-424.
Yunis EJ, Dibbins AW, Sherman FE:  Rectal suction biopsy in the diagnosis of Hirschsprung's disease in infants . Arch Pathol Lab Med 1976;;100: 329-333.
Swischuk LE:  Meconium plug syndrome: A cause of neonatal intestinal obstruction . AJR 1968;;103:339-346.
Pochaczevsky R, Leonidas JC:  The rectosigmoid index: A measurement for the early diagnosis of Hirschsprung's disease . AJR 1975;;123: 770-777.
Siegel MJ, Shackelford GD, McAlister WH:  The rectosigmoid index . Radiology 1981;;139:497-499.
Swenson O, Newhauser EBD, Picket LK:  New concepts of etiology, diagnosis and treatment of congenital megacolon (Hirschsprung's disease) . Pediatrics 1949;;4:201-209.
Ehrenpreis T:  Megacolon in the newborn: Clinical and roentgenological study with special regard to pathogenesis . Acta Paediatr 1945;;32: 358-370.
Berman CZ:  Roentgenographic manifestations of congenital megacolon (Hirschsprung's disease) in early infancy . Pediatrics 1956;;18:227-238.
Kleinhaus S, Boley SJ, Sheran M, et al:  Hirschsprung's disease: A survey of the members of the surgical section of the American Academy of Pediatrics . J Pediatr Surg 1979;;14:588-597.
Evans WA, Willis R:  Hirschsprung's disease: The roentgen diagnosis in infants . AJR 1957;;78:1024-1048.
McDonald RG, Evans WA:  Hirschsprung's disease: Roentgen diagnosis in infants . AJDC 1954;;87:575-585.
Rosenfeld NS, Ablow RC, Markowitz RI, et al:  Hirschsprung's disease: Accuracy of the barium enema examination . Radiology 1984;;150: 393-400.
Berdon WE, Baker DH:  The roentgenographic diagnosis of Hirschsprung's disease in infancy . AJR 1965;;93:432-446.
Schey WC, White H:  Hirschsprung's disease: Problems in the roentgen interpretation . AJR 1971;;112:105-115.
Swenson O, Sherman JO, Fisher JH:  Diagnosis of congenital megacolon: An analysis of 501 patients . J Pediatr Surg 1973;;8:587-593.
Kottmeier P, Clatworthy W:  Aganglionosis and functional megacolon in children: A diagnostic dilemma . Pediatrics 1965;;36:572-582.

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